Comparing Surgical and Oncological Outcomes between Indocyanine Green (ICG) Sentinel Lymph Node Mapping with Routine Lymphadenectomy in the Surgical Staging of Early-Stage Endometrioid Endometrial Cancer.

IF 1.6 Q3 OBSTETRICS & GYNECOLOGY
Obstetrics and Gynecology International Pub Date : 2023-10-17 eCollection Date: 2023-01-01 DOI:10.1155/2023/9949604
Krystal Miao Lin Koh, Zheng Yuan Ng, Felicia Hui Xian Chin, Wai Loong Wong, Junjie Wang, Yong Kuei Lim
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引用次数: 0

Abstract

Methods: A retrospective single-centre cohort study of patients with early-stage endometrioid endometrial cancer undergoing staging surgery (total hysterectomy, bilateral salpingo-oophorectomy with/without pelvic lymph node, and/or para-aortic lymph node dissection (PLND)) with either SLN mapping or routine lymphadenectomy between July 2017 and December 2018.

Results: 203 cases with clinical and radiological International Federation of Gynaecology and Obstetrics (FIGO) stage I endometrioid endometrial cancer were included, out of which 109 cases underwent SLN mapping and 94 cases complete lymphadenectomy. Compared to the PLND group, the SLN group had shorter operative time (129 vs. 162 minutes), less blood loss (100 vs. 300 ml), and decreased length of postoperative hospital stay (3 vs. 4 days) (p < 0.001). The lymph node metastases detection rate was 4.6% and 7.4% for the SLN and PLND groups, respectively (p = 0.389). With a median follow-up of 14 months for the SLN and 15 months for the PLND group, the disease-free (DFS) and overall survival (OS) were comparable for both at 13 months (p = 0.538 and p = 0.333, respectively).

Conclusion: SLN mapping has been shown to be an acceptable alternative to routine lymphadenectomy in the surgical staging of early-stage endometrial cancer in our centre, with a comparable lymph node metastases detection rate, DFS and OS, and reduction in operative morbidity. Our results with SLN mapping reproduce comparable outcomes to those reported in the literature.

Abstract Image

Abstract Image

Indocyanine Green(ICG)前哨淋巴结标测与常规淋巴结切除术在早期子宫内膜样子宫内膜癌症手术分期中的手术和肿瘤结果比较。
方法:2017年7月至2018年12月,对早期子宫内膜样子宫内膜癌症患者进行回顾性单中心队列研究,这些患者接受分期手术(全子宫切除术、双侧输卵管-卵巢切除术,带/不带盆腔淋巴结和/或皮质旁淋巴结清扫术(PLND)),并进行SLN标测或常规淋巴结清扫纳入国际妇产科联合会(FIGO)I期癌症,其中109例进行SLN标测,94例完成淋巴结切除术。与PLND组相比,SLN组的手术时间更短(129比162 分钟),减少失血(100 vs.300 ml),术后住院时间缩短(3比4 天)(p<0.001)。SLN组和PLND组的淋巴结转移检出率分别为4.6%和7.4%(p=0.389)。中位随访14 SLN的月数和15 PLND组的无病生存期(DFS)和总生存期(OS)在13个月时具有可比性 结论:在我们中心早期癌症的手术分期中,SLN标测已被证明是常规淋巴结切除术的一种可接受的替代方法,具有相当的淋巴结转移检测率、DFS和OS,并降低了手术发病率。我们的SLN标测结果与文献中报道的结果相当。
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来源期刊
Obstetrics and Gynecology International
Obstetrics and Gynecology International OBSTETRICS & GYNECOLOGY-
CiteScore
3.60
自引率
0.00%
发文量
26
审稿时长
19 weeks
期刊介绍: Obstetrics and Gynecology International is a peer-reviewed, Open Access journal that aims to provide a forum for scientists and clinical professionals working in obstetrics and gynecology. The journal publishes original research articles, review articles, and clinical studies related to obstetrics, maternal-fetal medicine, general gynecology, gynecologic oncology, uro-gynecology, reproductive medicine and infertility, reproductive endocrinology, and sexual medicine.
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