Associations of concurrent early-life famine exposure and adulthood obesity with type 2 diabetes mellitus in middle-aged Chinese

IF 3 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes Pub Date : 2023-10-26 DOI:10.1111/1753-0407.13480

Qian Yi, Jing Wu, Yaojia Shen, Yunying Zhu, Yiyang Zhou, He Bai, Jiajun Hao, Peige Song

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Abstract

Background

Evidence has shown that early-life famine exposure and obesity in adulthood are independently associated with the risk of type 2 diabetes mellitus (T2DM). However, few studies had revealed the combined effect of these risk factors.

Methods

Two sets of groups from the China Health and Retirement Longitudinal Study (CHARLS) were selected. The fetal-exposure group born in 1959–1961 from 2011 wave (N = 958) and nonexposure group born in 1963–1965 from 2015 wave (N = 1540) were selected as Comparison 1. The early childhood-exposure group born in 1955–1957 from 2011 wave (N = 1510) and fetal-exposure group born in 1959–1961 from 2015 wave (N = 943) were Comparison 2. Logistic regressions were applied to examine the associations of different famine exposure periods and obesity patterns with T2DM risk.

Results

Compared with nonexposed participants without central overweight/obesity in adulthood, central overweight/obesity in adulthood together with nonexposure (odds ratio [OR]: 1.89, 95% confidence interval [CI]: 1.19–3.00) or fetal-exposure (OR: 1.99, 95% CI: 1.23–3.23) was associated with higher risks of T2DM. Compared with the early childhood-exposure group, the fetal-exposed participants showed higher risks of T2DM (OR: 1.30, 95% CI: 1.02–1.66). The coexistence of fetal famine exposure and central overweight/obesity in adulthood was associated with higher risks of T2DM (OR: 1.82, 95% CI: 1.19–2.79). Consistent associations were observed among males and participants from less severely affected areas.

Conclusions

In conclusion, central overweight/obesity in adulthood is associated with the increased risk of T2DM, but the effect of early-life famine exposure is not very clear.

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中国中年人早期饥荒暴露和成年肥胖与2型糖尿病的相关性。

背景：有证据表明，早期生活中的饥荒暴露和成年后的肥胖与2型糖尿病（T2DM）的风险独立相关。然而，很少有研究揭示这些风险因素的综合作用。方法：从中国健康与退休纵向研究（CHARLS）中选择两组。1959-1961年出生的胎儿暴露组自2011年波（N = 958）和2015年出生于1963-1965年的非暴露组（N = 1540）作为比较1。从2011年波（N = 1510）和1959-1961年出生的2015波胎儿暴露组（N = 943）是比较2。应用Logistic回归检验不同饥荒暴露期和肥胖模式与T2DM风险的相关性。结果：与成年期无中心超重/肥胖的非暴露参与者相比，成年期中心超重/肥胖症与非暴露（比值比[OR]:1.89，95%置信区间[CI]:1.19-3.00）或胎儿暴露（OR:1.99，95%CI:1.23-23.23）与T2DM的高风险相关。与儿童早期暴露组相比，胎儿暴露组的参与者表现出更高的T2DM风险（OR:1.30，95%CI:1.02-1.66）。成年期胎儿饥荒暴露和中心性超重/肥胖的共存与T2DM的风险更高有关（OR:1.82，95%CI:1.19-2.79）。在男性和受影响较轻地区的参与者中观察到一致的相关性。结论：总之，成年期的中心性超重/肥胖与T2DM的风险增加有关，但早期饥荒暴露的影响尚不清楚。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Diabetes ENDOCRINOLOGY & METABOLISM-

CiteScore

6.50

自引率

2.20%

发文量

审稿时长

>12 weeks

期刊介绍： Journal of Diabetes (JDB) devotes itself to diabetes research, therapeutics, and education. It aims to involve researchers and practitioners in a dialogue between East and West via all aspects of epidemiology, etiology, pathogenesis, management, complications and prevention of diabetes, including the molecular, biochemical, and physiological aspects of diabetes. The Editorial team is international with a unique mix of Asian and Western participation. The Editors welcome submissions in form of original research articles, images, novel case reports and correspondence, and will solicit reviews, point-counterpoint, commentaries, editorials, news highlights, and educational content.