The Distinct Pattern of Granulomatous Lobular Mastitis with Erythema Nodosum: More Severe Conditions and Extensive Lesions.

IF 2.1 4区 医学 Q2 SURGERY
Journal of Investigative Surgery Pub Date : 2023-09-08 Epub Date: 2023-10-24 DOI:10.1080/08941939.2023.2257770
Bilian Zheng, Man Lu, Chuang Chen, Shengrong Sun
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引用次数: 0

Abstract

Purpose: Granulomatous lobular mastitis (GLM) is a benign inflammatory disease of the mammary gland with unknown etiology. Erythema nodosum (EN) is a rare, extramammary symptom of GLM. The purpose of this article was to investigate the clinical features of EN associated with GLM.

Methods: We recruited 102 GLM patients diagnosed between December 2018 and December 2021 at Renmin Hospital of Wuhan University. The clinical characteristics and laboratory indices of the EN group (n = 12) and the non-EN group (n = 90) were compared.

Results: The proportion of GLM patients with lesions involving ≥2 quadrants and high peripheral white blood cell count, absolute neutrophil count and neutrophil-to-lymphocyte ratio (NLR) was larger in the EN group than in the non-EN group (p = 0.002, 0.025, 0.014, 0.002, respectively). The duration of EN was longer in GLM patients with EN than in GLM patients without EN (p = 0.005). GLM patients with EN had more abscesses and sinus tracts than those without EN (p = 0.003, 0.038). Lesions involving ≥2 quadrants and the NLR were positively associated with the occurrence of EN (R = 0.304, 0.0302, p = 0.002, 0.002). Receiver operating characteristic curve analysis revealed that the area under the curve of the NLR was 0.770. When NLR > 5.73, the sensitivity and specificity of predicting EN were 66.67% and 87.78%, respectively.

Conclusion: Our findings suggest that GLM concomitant with EN suggests the presence of a more severe condition and extensive lesions.

小叶性肉芽肿性乳腺炎伴结节性红斑的独特模式:更严重的情况和广泛的病变。
目的:肉芽肿性小叶性乳腺炎(GLM)是一种病因不明的乳腺良性炎症性疾病。结节性红斑(EN)是一种罕见的GLM乳腺外症状。本文的目的是研究EN与GLM相关的临床特征。方法:我们招募了武汉大学人民医院2018年12月至2021年12月诊断的102名GLM患者。EN组(n = 12) 而非EN组(n = 90)进行比较。结果:GLM患者病变面积≥2个象限,外周血白细胞计数、中性粒细胞绝对计数和中性粒细胞与淋巴细胞比值(NLR)均高于非EN组(p = 分别为0.002、0.025、0.014、0.002)。有EN的GLM患者的EN持续时间长于无EN的GLM患者(p = 0.005)。患有EN的GLM患者比没有EN的患者有更多的脓肿和窦道(p = 涉及≥2个象限的病变和NLR与EN的发生呈正相关(R = 0.304,0.0302,p = 0.0020.002)。受试者工作特性曲线分析显示NLR的曲线下面积为0.770。当NLR>5.73时,预测EN的敏感性和特异性分别为66.67%和87.78%。结论:我们的研究结果表明,GLM合并EN表明存在更严重的情况和广泛的病变。
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来源期刊
CiteScore
4.20
自引率
0.00%
发文量
114
审稿时长
6-12 weeks
期刊介绍: Journal of Investigative Surgery publishes peer-reviewed scientific articles for the advancement of surgery, to the ultimate benefit of patient care and rehabilitation. It is the only journal that encompasses the individual and collaborative efforts of scientists in human and veterinary medicine, dentistry, basic and applied sciences, engineering, and law and ethics. The journal is dedicated to the publication of outstanding articles of interest to the surgical research community.
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