The microbiota and renal cell carcinoma.

IF 6.6 2区医学 Q1 Medicine

Cellular Oncology Pub Date : 2024-04-01 Epub Date: 2023-10-25 DOI:10.1007/s13402-023-00876-9

Ke Wu, Yaorong Li, Kangli Ma, Weiguang Zhao, Zhixian Yao, Zhong Zheng, Feng Sun, Xingyu Mu, Zhihong Liu, Junhua Zheng

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Abstract

Renal cell carcinoma (RCC) accounts for about 2% of cancer diagnoses and deaths worldwide. Recent studies emphasized the critical involvement of microbial populations in RCC from oncogenesis, tumor growth, and response to anticancer therapy. Microorganisms have been shown to be involved in various renal physiological and pathological processes by influencing the immune system function, metabolism of the host and pharmaceutical reactions. These findings have extended our understanding and provided more possibilities for the diagnostic or therapeutic development of microbiota, which could function as screening, prognostic, and predictive biomarkers, or be manipulated to prevent RCC progression, boost anticancer drug efficacy and lessen the side effects of therapy. This review aims to present an overview of the roles of microbiota in RCC, including pertinent mechanisms in microbiota-related carcinogenesis, the potential use of the microbiota as RCC biomarkers, and the possibility of modifying the microbiota for RCC prevention or treatment. According to these scientific findings, the clinical translation of microbiota is expected to improve the diagnosis and treatment of RCC.

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微生物群与肾细胞癌。

肾细胞癌（RCC）约占全球癌症诊断和死亡的2%。最近的研究强调了微生物种群在RCC中的关键参与，包括致癌、肿瘤生长和对抗癌治疗的反应。微生物已被证明通过影响免疫系统功能、宿主代谢和药物反应参与各种肾脏生理和病理过程。这些发现扩展了我们的理解，并为微生物群的诊断或治疗发展提供了更多的可能性，微生物群可以作为筛查、预后和预测生物标志物，或被操纵以预防RCC进展、提高抗癌药物疗效和减轻治疗副作用。这篇综述旨在概述微生物群在肾细胞癌中的作用，包括微生物群相关致癌作用的相关机制，微生物群作为肾细胞癌生物标志物的潜在用途，以及修改微生物群以预防或治疗肾细胞癌的可能性。根据这些科学发现，微生物群的临床转化有望改善RCC的诊断和治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cellular Oncology Biochemistry, Genetics and Molecular Biology-Cancer Research

CiteScore

10.40

自引率

1.50%

发文量

审稿时长

16 weeks

期刊介绍： The Official Journal of the International Society for Cellular Oncology Focuses on translational research Addresses the conversion of cell biology to clinical applications Cellular Oncology publishes scientific contributions from various biomedical and clinical disciplines involved in basic and translational cancer research on the cell and tissue level, technical and bioinformatics developments in this area, and clinical applications. This includes a variety of fields like genome technology, micro-arrays and other high-throughput techniques, genomic instability, SNP, DNA methylation, signaling pathways, DNA organization, (sub)microscopic imaging, proteomics, bioinformatics, functional effects of genomics, drug design and development, molecular diagnostics and targeted cancer therapies, genotype-phenotype interactions. A major goal is to translate the latest developments in these fields from the research laboratory into routine patient management. To this end Cellular Oncology forms a platform of scientific information exchange between molecular biologists and geneticists, technical developers, pathologists, (medical) oncologists and other clinicians involved in the management of cancer patients. In vitro studies are preferentially supported by validations in tumor tissue with clinicopathological associations.