An Exploration of Mineral Density, Elemental and Chemical Composition of Primary Teeth in Relation to Cord-Blood Vitamin D, Using Laboratory Analysis Techniques

IF 5.1 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Journal of Bone and Mineral Research Pub Date : 2023-10-25 DOI:10.1002/jbmr.4928

Deanna M Beckett, Shaun Vaz Viegas, Jonathan M Broadbent, Benjamin J Wheeler, Kārlis Bērziņš, Sara J Fraser-Miller, Keith C Gordon, Bernadette K Drummond, Erin K Mahoney, Carolina Loch

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Abstract

Postnatally, severe vitamin D deficiency commonly results in rickets as well as potential defects in tooth mineralization. The effects of milder deficiency on oral health outcomes later in life are still unclear. This study used micro–computed tomography (μCT), energy dispersive X-ray analysis (EDX), and Raman spectroscopy to investigate mineral density, total density, and elemental composition of enamel and dentine in 63 exfoliated primary incisors from participants with known 25-hydroxyvitamin D levels (25-OHD) at birth. No differences in mineralization and chemical composition using μCT and EDX analysis were observed irrespective of 25-OHD status. Subtle structural differences were observed via Raman spectroscopy, with more crystalline enamel observed in those with sufficient 25-OHD at birth. Although subtle, the differences seen suggest further attention should be given to children with known milder levels of vitamin D deficiency in early life. © 2023 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).

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利用实验室分析技术探索与脐带血维生素D有关的乳牙的矿物质密度、元素和化学组成。

产后，严重的维生素D缺乏通常会导致软骨病以及牙齿矿化的潜在缺陷。轻度缺乏对日后口腔健康结果的影响尚不清楚。本研究使用微型计算机断层扫描（Micro-CT）、能量分散X射线分析（EDX）和拉曼光谱研究了出生时已知25羟基维生素D水平（25-OHD）的63颗脱落原切牙的矿物质密度、总密度以及牙釉质和牙本质的元素组成。无论25-OHD状态如何，使用Micro-CT和EDX分析均未观察到矿化和化学成分的差异。通过拉曼光谱观察到细微的结构差异，在出生时有足够25-OHD的人身上观察到更多的结晶釉质。虽然存在细微差异，但这些差异表明，应进一步关注早期已知维生素D缺乏程度较轻的儿童。这篇文章受版权保护。保留所有权利。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Bone and Mineral Research 医学-内分泌学与代谢

CiteScore

11.30

自引率

6.50%

发文量

257

审稿时长

2 months

期刊介绍： The Journal of Bone and Mineral Research (JBMR) publishes highly impactful original manuscripts, reviews, and special articles on basic, translational and clinical investigations relevant to the musculoskeletal system and mineral metabolism. Specifically, the journal is interested in original research on the biology and physiology of skeletal tissues, interdisciplinary research spanning the musculoskeletal and other systems, including but not limited to immunology, hematology, energy metabolism, cancer biology, and neurology, and systems biology topics using large scale “-omics” approaches. The journal welcomes clinical research on the pathophysiology, treatment and prevention of osteoporosis and fractures, as well as sarcopenia, disorders of bone and mineral metabolism, and rare or genetically determined bone diseases.