Data mining analysis of professor Qiu Changlin's Chinese Medicinal therapy for Parkinson's disease

Medicine Advances Pub Date : 2023-08-30 DOI:10.1002/med4.28

Shuang Wu, Han Wu, Xuhong Jiang, Hongchen Li, Jie Luo

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Abstract

Background

Parkinson's disease (PD) is a prevalent, progressive neurodegenerative disease that has been widely treated using dopamine replacement therapy. However, this therapy does not prevent the progressive loss of dopaminergic neurons in the substantia nigra pars compacta. Clinical experience has shown that Chinese medicines (CMs) can alleviate the side effects of Western medicines for PD and improve the quality of life of patients.

Objective

This paper describes the collection and analysis of Professor Qiu Changlin's decoctions for PD and proposes new ideas on the Law of CM Clinical Formula Administration and Syndrome Differentiation of PD.

Methods

A database of Professor Qiu's prescriptions for PD patients of Zhejiang Provincial Hospital of Chinese Medicine over 5 years (January 2018 to May 2022) was established and analyzed using Microsoft Excel 2019 and SPSS Modeler 22.0.

Results

Frequency analysis of 1162 prescriptions comprising 232 CMs revealed 17 high-frequency CMs, including Shu Di Huang (Rehmanniae Radix Praeparata) and Chao Bai Shao (Paeoniae Radix Alba), and correlations among the CMs. The property (nature) of these CMs is warm, and the flavors are mainly bitter, sweet, and sour. Most enter the liver meridian. Based on cluster analysis, we obtained a core effective prescription that mainly comprises Tian Ma, Gou Teng Yin and Zuo Gui Wan.

Conclusion

The core effective prescription is expected to inspire new ideas for the administration of CM clinical formulas and syndrome differentiation in PD.

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邱长林教授中医治疗帕金森病的数据挖掘分析

背景帕金森病（PD）是一种流行的、进行性的神经退行性疾病，已被广泛使用多巴胺替代疗法进行治疗。然而，这种疗法并不能阻止黑质致密部多巴胺能神经元的逐渐丧失。临床经验表明，中药可以减轻西药治疗帕金森病的副作用，提高患者的生活质量。目的对邱长林教授治疗帕金森病的方药进行收集和分析，并对中医临床用药规律和帕金森病辨证规律提出新的见解建立浙江省中医院5年以上（2018年1月至2022年5月）的患者，并使用Microsoft Excel 2019和SPSS Modeler 22.0进行分析。结果对1162个处方（232个中药）进行频率分析，发现17个高频中药，包括熟地黄和芍药，并且这些中药之间存在相关性。这些CM的性质（性质）是温暖的，味道主要是苦、甜和酸。大多数进入肝经。基于聚类分析，我们得到了一个主要由天马、钩藤饮和左归丸组成的核心有效方。结论该核心有效方有望为中药临床用药及帕金森病辨证提供新思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Medicine Advances

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