Saponin-Encapsulated Microbubbles Protect Dopaminergic Neurons from MPTP-Induced Oxidative Stress Injury (Adv. Therap. 10/2023)

IF 3.7 4区医学 Q2 PHARMACOLOGY & PHARMACY

Advanced Therapeutics Pub Date : 2023-10-19 DOI:10.1002/adtp.202370027

Zhuxia Zhang, Bingxuan Xu, Tao Lv, Yu Shi, Mengxin Wang, Die Hu, Azhen Hu, Ping Li, Shuping Lin, Shengwei Zhang, Rongquan Yao, Lan Luo, Linlin Wang, Yiping Zhang, Yanni Han, Huiying Hu, Xintao Shuai, Jie Shi, Yun Chen, Tingting Zheng

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引用次数: 0

Abstract

Ginsenoside Rb₃ nanoparticles (Rb₃NPs) is a potential antioxidant for Parkinson's disease (PD) treatment. In Article 2300056, Xintao Shuai, Jie Shi, Yun Chen, Tingting Zheng, and co-workers introduce phospholipid microbubbles encapsulated Rb₃NPs (Rb₃NPs@MBs) with low intensity low frequency focused ultrasound to achieve brain targeted Rb₃NPs drug release. The treatment protects neurons from oxidative damage and slows PD progression. The article shows a perfect combination of traditional Chinese medicine with modern medical research in PD treatment.

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皂苷包裹的微泡保护多巴胺能神经元免受MPTP诱导的氧化应激损伤（Adv.Therap.10/2023）

人参皂苷Rb3纳米粒子（Rb3NP）是一种潜在的治疗帕金森病（PD）的抗氧化剂。在文章2300056中，Shuai Xintoo，Jie Shi，Yun Chen，Tingting Zheng及其同事介绍了包封Rb3NP的磷脂微泡(Rb3NPs@MBs)用低强度低频聚焦超声实现脑靶向Rb3NP药物释放。这种治疗可以保护神经元免受氧化损伤，减缓帕金森病的进展。本文展示了中医药与现代医学研究在帕金森病治疗中的完美结合。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Therapeutics Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

7.10

自引率

2.20%

发文量

130