Engineering of Interfaces with Tetrahedra DNA Nanostructures for Biosensing Applications

IF 3.4 Q2 CHEMISTRY, ANALYTICAL
Dr. Jinnan Xuan, Dr. Zhen Wang, Dr. Mingshu Xiao, Prof. Hao Pei
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引用次数: 0

Abstract

The probe-target interactions in the interfaces are significantly critical to biosensing. However, the disordered arrangement of probes and nonspecific adsorption of proteins in the biosensing interfaces for conventional biosensors often restricted the accessibility and recognition efficiency of probes towards targets, leading to poor detection performances (e. g., sensitivity and selectivity). Engineering of biosensing interfaces with functional molecules or nanomaterials has provided a promising molecular toolkit for enhanced accessibility and efficient recognition of biosensing probes. Among them, DNA has been an appealing material for interface engineering, because of its unique merits of biocompatible, predictable hybridization, and unparallel self-assembly ability. In particular, employing tetrahedra DNA nanostructures (TDNs) to engineer interfaces has been a powerful means to improve biosensor performance. Here, this review introduces the recent progress in TDN-based interface engineering. Then, we summarize the roles of TDNs in tailoring the properties of different interfaces, including electrode surface, channel surface, cell surface, etc., and highlight their biosensing applications. Finally, scientific challenges and future perspectives of TDN-engineered biosensing interface are also discussed.

Abstract Image

用于生物传感应用的四面体DNA纳米结构的界面工程
界面中的探针-靶标相互作用对生物传感至关重要。然而,传统生物传感器的探针排列紊乱和蛋白质在生物传感界面中的非特异性吸附往往限制了探针对目标的可及性和识别效率,导致检测性能较差(e.e。 g.灵敏度和选择性)。与功能分子或纳米材料的生物传感界面工程为增强生物传感探针的可及性和有效识别提供了一个很有前途的分子工具包。其中,DNA因其独特的生物相容性、可预测的杂交和不平行的自组装能力而成为界面工程的一种有吸引力的材料。特别是,采用四面体DNA纳米结构(TDN)来设计界面已经成为提高生物传感器性能的有力手段。本文介绍了基于TDN的接口工程的最新进展。然后,我们总结了TDN在调整不同界面(包括电极表面、通道表面、细胞表面等)特性方面的作用,并重点介绍了其生物传感应用。最后,还讨论了TDN工程生物传感接口的科学挑战和未来前景。
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CiteScore
2.60
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