Inside Back Cover: Small-molecule nanoprodrug with high drug loading and EGFR, PI3K/AKT dual-inhibiting properties for bladder cancer treatment (EXP2 5/2023)
Guoyin Li, Zewen Song, Yi Ru, Jing Zhang, Lianxiang Luo, Wei Yang, Hao Wu, Haibao Jin, Xuanwen Bao, Di Wei, Zhao Yan, Haijing Qu, Zheng Zhu, Gang Zhou
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Abstract
Overexpression of the EGFR is found in up to 74% of bladder cancer tissue. Two natural products that were found, triptolide (represented by lightning) and hesperidin (represented by orange), could inhibit EGFR pathways. They are linked together into a prodrug that can form nanoparticles (represented by oranges containing lightning), which not only remarkably improved their bioavailability and therapeutic but also reduced their systemic toxicity.
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