Injectable Porous Silicon Nanoparticles as a Plasma Cytokine Scavenger for Potentiating Cytokine Storm Syndrome Treatment

IF 4 Q2 ENGINEERING, BIOMEDICAL

Advanced Nanobiomed Research Pub Date : 2023-10-16 DOI:10.1002/anbr.202370101

Ruogu Qi, Shengliang Li, Feng Li, Junhua Mai, Yu Wang, Guixian Zhu, Dechen Zhang, Zheng Li, Haifa Shen, Jianliang Shen, Xuewu Liu

引用次数: 0

Abstract

Injectable Nanoparticles

Appropriate materials for the efficient and selective capturing of plasma cytokines are urgently needed. In article number 2300037, Jianliang Shen, Xuewu Liu, and co-workers design injectable porous silicon particles (PSPs) as scavenging adsorbents. The fabricated PSPs feature high porosity for large pore volume and high specific surface area, and a longer body circulation time. To facilitate specific recognition of targeting biomacromolecules, antibodies are immobilized on the interior surface of the PSPs.

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可注射多孔硅纳米粒子作为血浆细胞因子清除剂用于增强细胞因子风暴综合征的治疗

可注射纳米颗粒迫切需要用于有效和选择性捕获血浆细胞因子的合适材料。在文章编号2300037中，沈建良、刘学武及其同事设计了可注射多孔硅颗粒（PSP）作为清除吸附剂。所制备的PSP具有高孔隙率、大孔体积和高比表面积以及较长的体循环时间。为了促进靶向生物大分子的特异性识别，抗体被固定在PSP的内表面。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Nanobiomed Research nanomedicine, bioengineering and biomaterials-

CiteScore

5.00

自引率

5.90%

发文量

审稿时长

21 weeks

期刊介绍： Advanced NanoBiomed Research will provide an Open Access home for cutting-edge nanomedicine, bioengineering and biomaterials research aimed at improving human health. The journal will capture a broad spectrum of research from increasingly multi- and interdisciplinary fields of the traditional areas of biomedicine, bioengineering and health-related materials science as well as precision and personalized medicine, drug delivery, and artificial intelligence-driven health science. The scope of Advanced NanoBiomed Research will cover the following key subject areas: ▪ Nanomedicine and nanotechnology, with applications in drug and gene delivery, diagnostics, theranostics, photothermal and photodynamic therapy and multimodal imaging. ▪ Biomaterials, including hydrogels, 2D materials, biopolymers, composites, biodegradable materials, biohybrids and biomimetics (such as artificial cells, exosomes and extracellular vesicles), as well as all organic and inorganic materials for biomedical applications. ▪ Biointerfaces, such as anti-microbial surfaces and coatings, as well as interfaces for cellular engineering, immunoengineering and 3D cell culture. ▪ Biofabrication including (bio)inks and technologies, towards generation of functional tissues and organs. ▪ Tissue engineering and regenerative medicine, including scaffolds and scaffold-free approaches, for bone, ligament, muscle, skin, neural, cardiac tissue engineering and tissue vascularization. ▪ Devices for healthcare applications, disease modelling and treatment, such as diagnostics, lab-on-a-chip, organs-on-a-chip, bioMEMS, bioelectronics, wearables, actuators, soft robotics, and intelligent drug delivery systems. with a strong focus on applications of these fields, from bench-to-bedside, for treatment of all diseases and disorders, such as infectious, autoimmune, cardiovascular and metabolic diseases, neurological disorders and cancer; including pharmacology and toxicology studies.