Photo-facilitated chemodynamic therapeutic agents: Synthesis, mechanisms, and biomedical applications

BMEMat Pub Date : 2023-02-16 DOI:10.1002/bmm2.12005

Nan Yang, Changyu Cao, Xinyi Lv, Tian Zhang, Jinjun Shao, Xuejiao Song, Wenjun Wang, Peng Chen, Wei Huang, Xiaochen Dong

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引用次数: 15

Abstract

Chemodynamic therapy (CDT) utilizes Fenton and/or Fenton-like reactions in the tumor microenvironment (TME) to produce cytotoxic reactive oxygen species (ROS, mainly hydroxyl radicals, •OH) for inducing cancer cell death. Since CDT exhibits minimal invasiveness and high tumor specificity by responding to TME (overexpressed hydrogen peroxide (H₂O₂) and glutathione (GSH) generation), a lot of related research has been conducted recently. Photo-facilitated CDT can further enhance the catalytic activity and controllability of the treatment. In addition, other photo-induced therapies, including photodynamic and photothermal therapy (PDT, PTT), may synergize with CDT to obtain boosting treatment efficacy and avoid multidrug resistance. In this minireview, we summarize the recent advances in photo-assisted CDT, including PTT-facilitated CDT and PDT-facilitated CDT. More importantly, the challenges encountered in the treatment process are discussed and potential development directions are suggested to facilitate the clinical translation of photo-assisted CDT in the future.

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光促进化学动力学治疗剂：合成、机制和生物医学应用

化学动力学治疗（CDT）利用肿瘤微环境（TME）中的芬顿和/或芬顿样反应产生细胞毒性活性氧（ROS，主要是羟基自由基，•OH），用于诱导癌症细胞死亡。由于CDT通过对TME（过表达的过氧化氢（H2O2）和谷胱甘肽（GSH）的产生）的反应表现出最小的侵袭性和高的肿瘤特异性，最近进行了大量的相关研究。光促进CDT可以进一步提高处理的催化活性和可控性。此外，其他光诱导疗法，包括光动力和光热疗法（PDT，PTT），可能与CDT协同作用，以提高治疗效果并避免多药耐药性。在这篇小型综述中，我们总结了光辅助CDT的最新进展，包括PTT辅助CDT和PDT辅助CDT。更重要的是，讨论了治疗过程中遇到的挑战，并提出了潜在的发展方向，以促进未来光辅助CDT的临床翻译。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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