A chitosan-based hydrogel containing zinc oxide nanoparticles as a carrier for improving antibacterial activity and controlling the release of antibiotics

IF 1.5 4区材料科学 Q4 MATERIALS SCIENCE, MULTIDISCIPLINARY

Micro & Nano Letters Pub Date : 2023-07-04 DOI:10.1049/mna2.12172

Ali Rastegari, Fatemeh Hasanshakir, Zohreh Mohammadi, Fatemeh Saadatpor, Homa Faghihi, Fatemeh Moraffah

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Abstract

Microbial infections are considered one of the most important concerns of the world community. Developing drug delivery systems based on formulation of nanoparticles (NPs) with antimicrobial agents has shown beneficial effectiveness against microbial infections and related antimicrobial resistance. In this study, the authors prepared and characterized a chitosan-based hydrogel loaded with zinc oxide NPs for controlling the release of vancomycin and also improving its antibacterial effect. Characterization studies demonstrated that the developed biopolymeric hydrogel was able to sustain and control the release of vancomycin in response to acidic media for 96 h. Furthermore, antimicrobial studies showed significant and efficient antibacterial activity of prepared hydrogel against Staphylococcus aureus and Pseudomonas aeruginosa. Based on the obtained results, it can be concluded that the prepared chitosan hydrogel (CH) containing zinc oixde (ZnO) NPs has a desirable activity for controlling the release of vancomycin and improving its antibacterial properties.

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一种以氧化锌纳米粒子为载体的壳聚糖水凝胶，用于提高抗菌活性和控制抗生素的释放

微生物感染被认为是国际社会最关心的问题之一。基于纳米颗粒（NP）与抗菌剂的配方开发的药物递送系统已显示出对抗微生物感染和相关抗菌耐药性的有益效果。在本研究中，作者制备并表征了一种负载氧化锌纳米颗粒的壳聚糖水凝胶，用于控制万古霉素的释放并提高其抗菌效果。表征研究表明，所开发的生物聚合物水凝胶能够维持和控制万古霉素在酸性介质中的释放96小时。此外，抗菌研究表明，所制备的水凝胶对金黄色葡萄球菌和铜绿假单胞菌具有显著而有效的抗菌活性。基于所获得的结果，可以得出结论，所制备的含有氧化锌（ZnO）NPs的壳聚糖水凝胶（CH）在控制万古霉素的释放和提高其抗菌性能方面具有理想的活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Micro & Nano Letters 工程技术-材料科学：综合

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

2.8 months

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