Electrospun SrO-Incorporated Nanofiber Membranes for Biomedical Applications

IF 2.2 4区工程技术 Q1 MATERIALS SCIENCE, TEXTILES

Fibers and Polymers Pub Date : 2023-09-27 DOI:10.1007/s12221-023-00361-y

Zhe Chen, Jitao Fan, Yangfan Ding, Yunlong Zhang, Ahmed I. Abd-Elhamid, Jinglei Wu, Binbin Sun

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引用次数: 0

Abstract

Bioactive ceramics have gained increasing interest in biomedical applications. Strontium (Sr)-based ceramics show unique bioactivity in stimulating cell proliferation and migration and promoting angiogenesis. Incorporation of bioactive ceramics into nanofibers represents a facile approach to alter the material properties of electrospun nanofiber membranes. Herein, we prepared SrO-incorporated nanofiber membranes by electrospinning and investigated the effects of SrO particles on the physicochemical properties and cytocompatibility of these membranes. Our results indicate that simple one-stream electrospinning could smoothly introduce SrO particles into poly(L-lactic acid) (PLA)/gelatin nanofibers. SrO-incorporated membranes showed significantly improved wettability but became brittle compared with PLA/gelatin nanofiber membranes. Cells differentially responded to SrO-incorporated membranes: endothelial cells showed greater cell area and coverage on SrO-incorporated membranes; in contrast, fibroblasts were inhibited on these membranes. These findings suggest that SrO-incorporated membranes might find opportunities in specific biomedical applications in which pro-angiogenesis and antiadhesion are simultaneously demanded.

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生物医学应用的静电纺sro纳米纤维膜

生物活性陶瓷在生物医学应用中越来越受到关注。锶基陶瓷在刺激细胞增殖和迁移以及促进血管生成方面表现出独特的生物活性。将生物活性陶瓷掺入纳米纤维是改变电纺纳米纤维膜材料性能的一种简单方法。在此，我们通过静电纺丝制备了掺入SrO的纳米纤维膜，并研究了SrO颗粒对这些膜的物理化学性质和细胞相容性的影响。我们的结果表明，简单的单流静电纺丝可以顺利地将SrO颗粒引入聚L-乳酸（PLA）/明胶纳米纤维中。与PLA/明胶纳米纤维膜相比，掺入SrO的膜显示出显著改善的润湿性，但变得脆性。细胞对掺入SrO的膜有不同的反应：内皮细胞在掺入SrO的膜上显示出更大的细胞面积和覆盖率；相反，成纤维细胞在这些膜上受到抑制。这些发现表明，掺入SrO的膜可能在同时需要促血管生成和抗粘附的特定生物医学应用中找到机会。

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来源期刊

Fibers and Polymers 工程技术-材料科学：纺织

CiteScore

3.90

自引率

8.00%

发文量

267

审稿时长

3.9 months

期刊介绍： -Chemistry of Fiber Materials, Polymer Reactions and Synthesis- Physical Properties of Fibers, Polymer Blends and Composites- Fiber Spinning and Textile Processing, Polymer Physics, Morphology- Colorants and Dyeing, Polymer Analysis and Characterization- Chemical Aftertreatment of Textiles, Polymer Processing and Rheology- Textile and Apparel Science, Functional Polymers