Electrospun Janus core (ethyl cellulose//polyethylene oxide) @ shell (hydroxypropyl methyl cellulose acetate succinate) hybrids for an enhanced colon-targeted prolonged drug absorbance

IF 23.2 2区材料科学 Q1 MATERIALS SCIENCE, COMPOSITES

Advanced Composites and Hybrid Materials Pub Date : 2023-10-17 DOI:10.1007/s42114-023-00766-6

Jianfeng Zhou, Tao Yi, Zhiyuan Zhang, Deng-Guang Yu, Ping Liu, Liangzhe Wang, Yuanjie Zhu

{"title":"Electrospun Janus core (ethyl cellulose//polyethylene oxide) @ shell (hydroxypropyl methyl cellulose acetate succinate) hybrids for an enhanced colon-targeted prolonged drug absorbance","authors":"Jianfeng Zhou, Tao Yi, Zhiyuan Zhang, Deng-Guang Yu, Ping Liu, Liangzhe Wang, Yuanjie Zhu","doi":"10.1007/s42114-023-00766-6","DOIUrl":null,"url":null,"abstract":"<div><p>Structural polymeric nanohybrids is presently a popular topic and can be conceived for numerous functional applications, including the pH-sensitive oral colon-targeted drug-delivery system. In this paper, a brand-new Janus core@shell (JCS) nanostructure was fabricated using a trifluid electrospinning, in which three polymers and a model drug 5-fluorouracil (5-FU) were elaborately and intentionally positioned. In the structural hybrids, the pH-sensitive polymer hydroxypropyl methyl cellulose acetate succinate was located in the common shell layer, and the 5-FU-loaded ethyl cellulose (EC) and polyethylene oxide (PEO) were organized in a side-by-side manner in the core sections. The JCS fiber had a fine linear morphology with a multiple-chamber structure and a shell thickness of about 24 nm. The drug presented in the fibers in an amorphous state, owing to the secondary intermolecular interactions between EC and 5-FU. The ex vivo adhesion experiments suggested that the JCS fibers could stick firmly to the intestine membranes. In vitro dissolution tests showed the JCS fibers released only 7.8% ± 3.5% of the loaded 5-FU in an acid condition. In vivo gavage administration verified that the JCS fibers effectively promoted the absorbance of 5-FU in a synergistic manner, better than the double-layer core–shell and Janus nanofibers, and near fourfold than the drug solutions as a control. The present protocol opens a new way for developing novel multifunctional nanomaterials with the JCS nanostructure as a powerful supporting platform.</p><h3>Graphical abstract</h3>\n <div><figure><div><div><picture><source><img></source></picture></div></div></figure></div>\n </div>","PeriodicalId":7220,"journal":{"name":"Advanced Composites and Hybrid Materials","volume":"6 6","pages":""},"PeriodicalIF":23.2000,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Composites and Hybrid Materials","FirstCategoryId":"88","ListUrlMain":"https://link.springer.com/article/10.1007/s42114-023-00766-6","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, COMPOSITES","Score":null,"Total":0}

引用次数: 5

Abstract

Structural polymeric nanohybrids is presently a popular topic and can be conceived for numerous functional applications, including the pH-sensitive oral colon-targeted drug-delivery system. In this paper, a brand-new Janus core@shell (JCS) nanostructure was fabricated using a trifluid electrospinning, in which three polymers and a model drug 5-fluorouracil (5-FU) were elaborately and intentionally positioned. In the structural hybrids, the pH-sensitive polymer hydroxypropyl methyl cellulose acetate succinate was located in the common shell layer, and the 5-FU-loaded ethyl cellulose (EC) and polyethylene oxide (PEO) were organized in a side-by-side manner in the core sections. The JCS fiber had a fine linear morphology with a multiple-chamber structure and a shell thickness of about 24 nm. The drug presented in the fibers in an amorphous state, owing to the secondary intermolecular interactions between EC and 5-FU. The ex vivo adhesion experiments suggested that the JCS fibers could stick firmly to the intestine membranes. In vitro dissolution tests showed the JCS fibers released only 7.8% ± 3.5% of the loaded 5-FU in an acid condition. In vivo gavage administration verified that the JCS fibers effectively promoted the absorbance of 5-FU in a synergistic manner, better than the double-layer core–shell and Janus nanofibers, and near fourfold than the drug solutions as a control. The present protocol opens a new way for developing novel multifunctional nanomaterials with the JCS nanostructure as a powerful supporting platform.

Graphical abstract

Abstract Image

查看原文本刊更多论文

Electrospun Janus核心(乙基纤维素//聚乙烯氧化物)@壳(羟丙基甲基纤维素醋酸琥珀酸酯)杂交体，增强结肠靶向延长药物吸收

结构聚合物纳米杂化物目前是一个热门话题，可用于许多功能应用，包括pH敏感的口服结肠靶向药物递送系统。在本文中，一个全新的Januscore@shell（JCS）纳米结构是使用三氟甲流电纺丝制备的，其中三种聚合物和一种模型药物5-氟尿嘧啶（5-FU）被精心和有意地定位。在结构杂化物中，pH敏感聚合物乙酸-琥珀酸羟丙基甲基纤维素位于共同的壳层中，5-FU负载的乙基纤维素（EC）和聚环氧乙烷（PEO）以并排的方式在核心部分中组织。JCS纤维具有精细的线性形态，具有多腔室结构和约24nm的外壳厚度。由于EC和5-FU之间的二次分子间相互作用，药物以无定形状态存在于纤维中。离体粘附实验表明，JCS纤维可以牢固地粘附在肠膜上。体外溶出度测试显示JCS纤维仅释放7.8% ± 3.5%的负载5-FU在酸性条件下。体内灌胃给药验证了JCS纤维以协同方式有效促进5-FU的吸收，比双层核壳和Janus纳米纤维更好，并且比作为对照的药物溶液高出近四倍。本协议为开发以JCS纳米结构为强大支撑平台的新型多功能纳米材料开辟了一条新途径。图形摘要

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Advanced Composites and Hybrid Materials Multiple-

CiteScore

26.00

自引率

21.40%

发文量

185

期刊介绍： Advanced Composites and Hybrid Materials is a leading international journal that promotes interdisciplinary collaboration among materials scientists, engineers, chemists, biologists, and physicists working on composites, including nanocomposites. Our aim is to facilitate rapid scientific communication in this field. The journal publishes high-quality research on various aspects of composite materials, including materials design, surface and interface science/engineering, manufacturing, structure control, property design, device fabrication, and other applications. We also welcome simulation and modeling studies that are relevant to composites. Additionally, papers focusing on the relationship between fillers and the matrix are of particular interest. Our scope includes polymer, metal, and ceramic matrices, with a special emphasis on reviews and meta-analyses related to materials selection. We cover a wide range of topics, including transport properties, strategies for controlling interfaces and composition distribution, bottom-up assembly of nanocomposites, highly porous and high-density composites, electronic structure design, materials synergisms, and thermoelectric materials. Advanced Composites and Hybrid Materials follows a rigorous single-blind peer-review process to ensure the quality and integrity of the published work.