The border between obesity and metabolic disease in children and adolescents. Why and how to investigate? A review of the literature

IF 1.9 Q3 ENDOCRINOLOGY & METABOLISM

Human Nutrition and Metabolism Pub Date : 2023-09-01 DOI:10.1016/j.hnm.2023.200208

Marília Dornelles Bastos , Fabiana Assmann Poll , Cézane Priscila Reuter , Beatriz Dornelles Bastos , Gabriela Menta Endres , Giovana Maria Fontana Weber , Luciana Silva dos Santos

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引用次数: 0

Abstract

The prevalence of childhood overweight and obesity is increasing around the world, which is generating a search for new diagnostic alternatives. Differentiating between metabolically healthy and metabolically unhealthy individuals can help both in the therapeutic plan and in the prognostic view. In this review, we will address the role of the following markers: total cholesterol, high-density cholesterol; low density lipoprotein; triglycerides; uric acid; fasting blood glucose; glycated haemoglobin; insulin; C-peptide; interleukin-6; tumour necrosis factor-α; C-reactive protein; adipokines (leptin and adiponectin); micro ribonucleic acids, plasminogen activator inhibitor type 1, alanine aminotransferase, aspartate aminotransferase, vitamin D and thyroid-stimulating hormone. The presentation of specific reference values for children and adolescents in an objective and practical way will allow the identification the best moment for intervention in this population group.

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儿童和青少年肥胖与代谢性疾病之间的界限。为什么要调查?如何调查?文献综述

世界各地儿童超重和肥胖的患病率正在上升，这促使人们寻找新的诊断替代品。区分代谢健康和代谢不健康的个体有助于制定治疗计划和预后。在这篇综述中，我们将讨论以下标志物的作用：总胆固醇、高密度胆固醇；低密度脂蛋白；甘油三酯；尿酸；空腹血糖；糖化血红蛋白；胰岛素C-肽；白细胞介素-6；肿瘤坏死因子-α；C反应蛋白；脂肪因子（瘦素和脂联素）；微量核糖核酸、纤溶酶原激活物抑制剂1型、丙氨酸氨基转移酶、天冬氨酸氨基转移酶，维生素D和促甲状腺激素。以客观和实际的方式为儿童和青少年提供具体的参考值，将有助于确定对这一人群进行干预的最佳时机。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Human Nutrition and Metabolism Agricultural and Biological Sciences-Food Science

CiteScore

1.50

自引率

0.00%

发文量

审稿时长

188 days