Evaluation of the impact before and after the application of an antimicrobial stewardship program at Dong Thap General Hospital, Vietnam, from 2017 to 2021

IF 1.8 Q3 INFECTIOUS DISEASES
Hai-Yen Nguyen-Thi , Tran Viet Bui , Hong-Nguyen Tran-Thi , Anh Dang Minh Le , Bao Dang Gia Nguyen , Hong-Nhung Tran-Thi , Thien Nguyen , Nguyen Dang Tu Le
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引用次数: 0

Abstract

Background

Vietnam has one of the highest rates of antibiotic resistance in Asia. In 2020, the Vietnam Minister of Health introduced new legislation for the implementation of an antimicrobial stewardship program (ASP). The evidence for the effectiveness of ASP in small hospitals and hospitals located in provinces was limited compared with larger-scale and central city hospitals.

Aim

Evaluation of the impact before and after the introduction of an antimicrobial stewardship program at Dong Thap General Hospital, from 2017 to 2021.

Methods

Retrospective data was collected from June 2017 to June 2021. The impact of the ASP on changes in antibiotic use and the clinical outcome associated with the implementation of the ASP was evaluated using autoregressive integrated moving average modelling of controlled interrupted time-series analysis.

Results

There was a significant and sustained decrease in antibiotic consumption level (step change) in 2 indicators, DOT/1000PD (129.55; P<0.01) and LOT/1000PD (99.95, P<0.01), immediately after the ASP intervention. There were no statistically significant changes identified in terms of consumption with DDD/1000PD, or in the clinical outcomes. The results showed no statistically significant change in consumption trend (ramps) in all evaluated indicators. No statistically significant changes in consumption levels and trends were observed in the control group.

Conclusion

The ASP implemented in Dong Thap General Hospital from 2017 to 2021 showed a considerable influence on antibiotic consumption as indicated by the DOT/1000 PD and LOT/1000 PD during the initial stages. Moreover, controlling antibiotic consumption did not negatively impact patient outcomes.

2017年至2021年越南Dong Thap总医院应用抗菌药物管理计划前后的影响评估
越南是亚洲抗生素耐药性最高的国家之一。2020年,越南卫生部长提出了实施抗微生物药物管理规划(ASP)的新立法。与大型医院和中心城市医院相比,小型医院和省级医院ASP有效性的证据有限。目的评估2017年至2021年东塔综合医院引入抗菌药物管理方案前后的影响。方法回顾性收集2017年6月至2021年6月的数据。ASP对抗生素使用变化的影响,以及与ASP实施相关的临床结果,采用控制中断时间序列分析的自回归综合移动平均模型进行评估。结果2项指标DOT/1000PD (129.55;P<0.01)和LOT/1000PD (99.95, P<0.01)。在DDD/1000PD的消耗方面,或在临床结果方面,没有统计学上显著的变化。结果显示,所有评价指标的消费趋势(斜坡)没有统计学上的显著变化。在对照组中,消费水平和趋势没有统计学上的显著变化。结论2017 - 2021年实施的ASP对前期DOT/1000 PD和LOT/1000 PD的抗生素用量有较大影响。此外,控制抗生素的使用对患者的预后没有负面影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Infection Prevention in Practice
Infection Prevention in Practice Medicine-Public Health, Environmental and Occupational Health
CiteScore
4.80
自引率
0.00%
发文量
58
审稿时长
61 days
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