Solubility of famotidine in supercritical carbon dioxide: Experimental measurement and thermodynamic modeling

IF 3.4 3区工程技术 Q2 CHEMISTRY, PHYSICAL

Journal of Supercritical Fluids Pub Date : 2023-10-01 DOI:10.1016/j.supflu.2023.106031

Nedasadat Saadati Ardestani , Seyed Ali Sajadian , Adrián Rojas , Ratna Surya Alwi , L. Antonio Estévez

{"title":"Solubility of famotidine in supercritical carbon dioxide: Experimental measurement and thermodynamic modeling","authors":"Nedasadat Saadati Ardestani , Seyed Ali Sajadian , Adrián Rojas , Ratna Surya Alwi , L. Antonio Estévez","doi":"10.1016/j.supflu.2023.106031","DOIUrl":null,"url":null,"abstract":"<div>In the current study, the solubility of famotidine (FAM) in supercritical carbon dioxide (scCO₂) was experimentally determined for the first time. The FAM solubility in scCO₂, expressed as mole fraction, at different temperatures (308 − 338 K) and pressures (12 − 30 MPa) was found to be in the range of 1.40 × 10−6 to 1.11 × 10−4. Due to the low solubility of FAM in scCO₂, the gas anti-solvent and supercritical anti-solvent processes can be a good option to generate the nano/micro size particles of this drug. The experimental solubility data were correlated by the density-based models of Bartle et al., Méndez-Santiago and Teja (MST), Jouyban et al. and Hozhabr et al., by the non-cubic equation of state PC-SAFT, and by the two versions of the Estévez et al. model (ECM-PR and ECM-RK). According to the modeling results, the Estévez et al. model showed the highest accuracy with AARD values of 9.92 (ECM-PR) and 10.70 (ECM-RK). The empirical models also yielded satisfactory outcomes to the correlation of the solubility of FAM in scCO₂.</div>","PeriodicalId":17078,"journal":{"name":"Journal of Supercritical Fluids","volume":"201 ","pages":"Article 106031"},"PeriodicalIF":3.4000,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Supercritical Fluids","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S089684462300195X","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}

引用次数: 1

Abstract

In the current study, the solubility of famotidine (FAM) in supercritical carbon dioxide (scCO₂) was experimentally determined for the first time. The FAM solubility in scCO₂, expressed as mole fraction, at different temperatures (308 − 338 K) and pressures (12 − 30 MPa) was found to be in the range of 1.40 × 10⁻⁶ to 1.11 × 10⁻⁴. Due to the low solubility of FAM in scCO₂, the gas anti-solvent and supercritical anti-solvent processes can be a good option to generate the nano/micro size particles of this drug. The experimental solubility data were correlated by the density-based models of Bartle et al., Méndez-Santiago and Teja (MST), Jouyban et al. and Hozhabr et al., by the non-cubic equation of state PC-SAFT, and by the two versions of the Estévez et al. model (ECM-PR and ECM-RK). According to the modeling results, the Estévez et al. model showed the highest accuracy with AARD values of 9.92 (ECM-PR) and 10.70 (ECM-RK). The empirical models also yielded satisfactory outcomes to the correlation of the solubility of FAM in scCO₂.

Abstract Image

查看原文本刊更多论文

法莫替丁在超临界二氧化碳中的溶解度:实验测量和热力学模型

在目前的研究中，法莫替丁（FAM）在超临界二氧化碳（scCO）中的溶解度₂) 首次通过实验确定。FAM在scCO中的溶解度₂, 在不同温度（308−338 K）和压力（12−30 MPa）下，以摩尔分数表示的摩尔分数在1.40×10−6至1.11×10−4的范围内。由于FAM在scCO中的溶解度低₂, 气体反溶剂和超临界反溶剂工艺可以很好地产生该药物的纳米/微米颗粒。实验溶解度数据通过Bartle等人、Méndez-Santiago和Teja（MST）、Jouyban等人和Hozhabr等人的基于密度的模型、非三次状态方程PC-SAFT和Estévez等人模型的两个版本（ECM-PR和ECM-RK）进行关联。根据建模结果，Estévez等人的模型显示出最高的精度，AARD值分别为9.92（ECM-PR）和10.70（ECM-RK）。经验模型也对FAM在scCO中的溶解度的相关性产生了令人满意的结果₂.

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Supercritical Fluids 工程技术-工程：化工

CiteScore

7.60

自引率

10.30%

发文量

236

审稿时长

56 days

期刊介绍： The Journal of Supercritical Fluids is an international journal devoted to the fundamental and applied aspects of supercritical fluids and processes. Its aim is to provide a focused platform for academic and industrial researchers to report their findings and to have ready access to the advances in this rapidly growing field. Its coverage is multidisciplinary and includes both basic and applied topics. Thermodynamics and phase equilibria, reaction kinetics and rate processes, thermal and transport properties, and all topics related to processing such as separations (extraction, fractionation, purification, chromatography) nucleation and impregnation are within the scope. Accounts of specific engineering applications such as those encountered in food, fuel, natural products, minerals, pharmaceuticals and polymer industries are included. Topics related to high pressure equipment design, analytical techniques, sensors, and process control methodologies are also within the scope of the journal.