Inorganic virus-like nanoparticles for biomedical applications: a minireview

IF 5.2 Q1 FOOD SCIENCE & TECHNOLOGY
Liying Zhao , Jiahong Zhou , Dawei Deng
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引用次数: 0

Abstract

Nature has the ingenious capability to design spiky topological features at the macro-and nanoscales, which exhibits fascinating interface adhesive properties by means of multivalent interactions. Following a biomimetic approach, such as nanoscale virus particles are highly infectious toward host cells, a range of organic and inorganic spiky particles (virus-like nanostructures) have been precisely engineered for diverse biomedical applications. Generally, organic virus-like particles (VLPs) derived from viral capsids (often termed as virosomes) have been extensively studied and reviewed, but concomitant concerns regarding immunogenicity and risks of mutagenesis limit clinical potential of organic VLPs. In contrast, inorganic VLPs (viral-mimicking topography) possess fascinating physicochemical characteristics, such as excellent electrical, optical, magnetic, mechanical and catalytic properties, which make them particularly suitable for biomedical applications. Alternatively, there is no comprehensive review related to inorganic VLPs engineered with non-viral shell for biomedical applications. Hence, in this review, we present a brief overview on inorganic VLPs, followed by summarizing the construction and properties of virus-like nanostructures, as well as the mechanisms of nano-bio interface interactions initiated by spiky topography. Furthermore, we focus on the recent advances of VLPs for biomedical applications (including biosensing, antibacterial therapy and cancer treatment). Finally, the future outlook and emerging challenges will be presented. This review aims to provide future scope of the rational design of inorganic non-viral vectors, especially with respect to gene-based therapy platforms.

生物医学应用的无机类病毒纳米颗粒:综述
大自然有能力在宏观和纳米尺度上设计尖锐的拓扑特征,通过多价相互作用展现出迷人的界面粘合特性。根据仿生方法,例如纳米级病毒颗粒对宿主细胞具有高度传染性,一系列有机和无机尖峰颗粒(病毒样纳米结构)已被精确设计用于各种生物医学应用。通常,来源于病毒衣壳(通常称为病毒体)的有机病毒样颗粒(VLP)已被广泛研究和综述,但随之而来的免疫原性和诱变风险限制了有机VLP的临床潜力。相比之下,无机VLP(病毒模拟形貌)具有迷人的物理化学特性,如优异的电学、光学、磁学、机械和催化性能,这使它们特别适合生物医学应用。或者,还没有关于用非病毒外壳设计的用于生物医学应用的无机VLP的全面综述。因此,在这篇综述中,我们简要概述了无机VLP,然后总结了病毒样纳米结构的构建和性质,以及由尖峰形貌引发的纳米-生物界面相互作用的机制。此外,我们还重点介绍了VLP在生物医学应用(包括生物传感、抗菌治疗和癌症治疗)方面的最新进展。最后,将介绍未来前景和新出现的挑战。这篇综述旨在为无机非病毒载体的合理设计提供未来的范围,特别是在基于基因的治疗平台方面。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
5.80
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0.00%
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