Edge-Enhancing Gradient Echo MRI at 7T for detection of focal cortical dysplasia in epilepsy

Q4 Neuroscience

Neuroimage. Reports Pub Date : 2023-09-24 DOI:10.1016/j.ynirp.2023.100187

Erik H. Middlebrooks , Elena Greco , Xiangzhi Zhou , Vivek Gupta , Brin E. Freund , Amit K. Agarwal , Erin M. Westerhold , Anteneh M. Feyissa , William O. Tatum IV , Sanjeet Grewal , Vishal Patel , Shengzhen Tao

{"title":"Edge-Enhancing Gradient Echo MRI at 7T for detection of focal cortical dysplasia in epilepsy","authors":"Erik H. Middlebrooks , Elena Greco , Xiangzhi Zhou , Vivek Gupta , Brin E. Freund , Amit K. Agarwal , Erin M. Westerhold , Anteneh M. Feyissa , William O. Tatum IV , Sanjeet Grewal , Vishal Patel , Shengzhen Tao","doi":"10.1016/j.ynirp.2023.100187","DOIUrl":null,"url":null,"abstract":"<div><p>3D-Edge Enhancing Gradient Echo MRI (EDGE) is a promising method for identifying focal cortical dysplasia (FCD) because of its superior contrast-to-noise ratio. Gains in signal-to-noise ratio (SNR) and spatial resolution using 7T MRI should further enhance the utility of EDGE; however, the exquisite sensitivity to the optimal inversion time makes translation to 7T challenging given the extreme nonuniformities in the transmit field (B1+). By utilizing a combined MP2RAGE-EDGE sequence, the efficiency of the acquisition can be optimized to improve B1+ transmit uniformity and SNR. Using this approach, we report the first experience of using 7T EDGE MRI for the diagnosis of FCD in epilepsy, showing the feasibility of achieving high spatial resolution, SNR, and image contrast uniformity. EDGE-MP2RAGE sequence improves the detection of gray-white matter junction abnormalities associated with FCD and is a valuable, time-efficient addition to a 7T MR protocol in patients with focal epilepsy.</p></div>","PeriodicalId":74277,"journal":{"name":"Neuroimage. Reports","volume":"3 4","pages":"Article 100187"},"PeriodicalIF":0.0000,"publicationDate":"2023-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuroimage. Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666956023000326","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Neuroscience","Score":null,"Total":0}

引用次数: 0

Abstract

3D-Edge Enhancing Gradient Echo MRI (EDGE) is a promising method for identifying focal cortical dysplasia (FCD) because of its superior contrast-to-noise ratio. Gains in signal-to-noise ratio (SNR) and spatial resolution using 7T MRI should further enhance the utility of EDGE; however, the exquisite sensitivity to the optimal inversion time makes translation to 7T challenging given the extreme nonuniformities in the transmit field (B1+). By utilizing a combined MP2RAGE-EDGE sequence, the efficiency of the acquisition can be optimized to improve B1+ transmit uniformity and SNR. Using this approach, we report the first experience of using 7T EDGE MRI for the diagnosis of FCD in epilepsy, showing the feasibility of achieving high spatial resolution, SNR, and image contrast uniformity. EDGE-MP2RAGE sequence improves the detection of gray-white matter junction abnormalities associated with FCD and is a valuable, time-efficient addition to a 7T MR protocol in patients with focal epilepsy.

查看原文本刊更多论文

7T边缘增强梯度回波MRI检测癫痫局灶性皮质发育不良

3d边缘增强梯度回声MRI (EDGE)是一种很有前途的识别局灶性皮质发育不良(FCD)的方法，因为它具有优越的对比噪声比。7T MRI的信噪比(SNR)和空间分辨率的提高将进一步增强EDGE的实用性;然而，考虑到发射场的极端不均匀性(B1+)，对最佳反演时间的敏感使得转换到7T具有挑战性。通过组合MP2RAGE-EDGE序列，可以优化采集效率，提高B1+发射均匀性和信噪比。使用这种方法，我们报告了首次使用7T EDGE MRI诊断癫痫FCD的经验，显示了实现高空间分辨率、信噪比和图像对比度均匀性的可行性。EDGE-MP2RAGE序列改善了FCD相关灰质-白质连接异常的检测，是局灶性癫痫患者7T MR方案的宝贵、高效补充。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Neuroimage. Reports Neuroscience (General)

CiteScore

1.90

自引率

0.00%

发文量

审稿时长

87 days