Serum concentrations of retinol, β-carotene and zinc in women with breast cancer submitted to radiotherapy according to prior treatment modality and toxicity

IF 1.9 Q3 ENDOCRINOLOGY & METABOLISM
Cintia Rosa , Carlos Franca , Sérgio Lanes , Antônio Carvalho , Antônio Penna , Carla Nogueira , Mariana Luna , Andrea Ramalho
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Abstract

Objective

To analyze serum concentrations of retinol, β-carotene and zinc in women with breast cancer undergoing radiotherapy, considering different modalities of previous treatment and toxic effects.

Methods

longitudinal study in a cohort of women with breast cancer assessed in pre-treatment (T0), 7 (T2) and 120 (T3) days after radiation therapy. Patients were divided into 3 groups, according to treatment modality prior radiation: breast-conserving surgery (G1), chemotherapy (G2) and breast-conserving surgery and chemotherapy (G3). Serum concentrations of retinol, β-carotene and zinc was assessed. Presence and degree of toxicity were assessed according to the scale of the RTOG for and RTOG/EORTC for acute and late toxicity, respectively.

Results

230 patients were assessed, mean age of 63.6 (±9.3) years. There was significant reduction in the mean of all micronutrients studied when comparing T0 to T1. At T2, all nutrients increased when compared to T1. For acute toxicity, there was no difference in antioxidant levels according to the degree of toxicity for any of the groups, with the exception of G3, which presented lower serum zinc concentrations in women with a higher degree of acute toxicity. In late toxicity, G1 had lower serum concentrations of retinol and B-carotene, when compared to G2 and G3.

Conclusion

The significant reduction of all micronutrients after radiotherapy, regardless of the type of the previous treatment, reinforces the oxidative impact of radiation and draws attention to the importance of maintaining an adequate nutritional status of antioxidants to improve the prognosis.

Abstract Image

根据先前的治疗方式和毒性,接受放疗的乳腺癌妇女血清视黄醇、β-胡萝卜素和锌的浓度
目的分析癌症放疗后不同治疗方式及不同毒副作用妇女血清视黄醇、β-胡萝卜素和锌的浓度。方法对一组癌症妇女在放疗前(T0)、放疗后7(T2)和放疗后120(T3)天进行纵向研究。根据放疗前的治疗方式,将患者分为3组:保乳手术(G1)、化疗(G2)、保乳手术和化疗(G3)。评估血清视黄醇、β-胡萝卜素和锌的浓度。毒性的存在和程度分别根据急性和晚期毒性的RTOG和RTOG/EORTC的规模进行评估。结果对230例患者进行了评估,平均年龄63.6(±9.3)岁。当比较T0和T1时,所研究的所有微量营养素的平均值都显著降低。在T2,与T1相比,所有营养物质都增加了。对于急性毒性,根据毒性程度,任何一组的抗氧化剂水平都没有差异,但G3除外,G3在急性毒性程度较高的女性中表现出较低的血清锌浓度。在晚期毒性中,与G2和G3相比,G1的血清视黄醇和B-胡萝卜素浓度较低。结论放疗后所有微量营养素的显著减少,无论之前的治疗类型如何,增强了辐射的氧化影响,并提请注意保持抗氧化剂的充足营养状态对改善预后的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Human Nutrition and Metabolism
Human Nutrition and Metabolism Agricultural and Biological Sciences-Food Science
CiteScore
1.50
自引率
0.00%
发文量
30
审稿时长
188 days
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