Coagulant compounds in Rubia cordifolia L.

IF 5.2 Q1 FOOD SCIENCE & TECHNOLOGY

Journal of Future Foods Pub Date : 2023-09-01 DOI:10.1016/j.jfutfo.2023.02.003

Peiqing Wang , Jiajia Wang , Fatma M. El-Demerdash , Jinfeng Wei

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引用次数: 0

Abstract

Rubia cordifolia L. belongs to Rubiaceae family. Its medicinal parts are mainly root and rhizome, which is included in the Chinese Pharmacopoeia (2020), has the effect of cooling blood and stopping bleeding, removing stasis and channeling menstruation. However, studies on the hemostatic effect of R. cordifolia mainly focus on extracts, and the hemostatic components are less studied. Therefore, chemical constituents and coagulant activity of R. cordifolia were investigated in this paper. Eleven compounds were isolated and identified from R. cordifolia, including 1-hydroxy-2-methyl-9,10-anthraquinone (1), 1,4-dihydroxy-2-methylanthraquinone (2), palmitic acid (3), tricosanoic acid (4), ω-hydroxypachybasin (5), ursolic acid (6), oleanolic acid (7), rubilactone (8), β-sitosterol (9), cordifoliol (10), 1,3-dihydroxy-2-ethoxymethyl-9,10-anthraquinone (11). ω-Hydroxypachybasin was isolated from Rubia genus for the first time. 1,4-Dihydroxy-2-methylanthraquinone, rubilactone and 1,3-dihydroxy-2-ethoxymethyl-9,10-anthraquinone could remarkably shorten the plasma calcium coating time in vitro, thus indicating that they had procoagulant activity.

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芦花中的混凝剂成分。

茜草属茜草科。其药用部位以根和根茎为主，已被列入《中国药典(2020)》，具有凉血止血、化瘀通经的功效。然而，对堇青花止血作用的研究主要集中在提取物上，对其止血成分的研究较少。因此，本文对堇青花的化学成分和混凝剂活性进行了研究。从堇青花中分离鉴定了11个化合物，分别为1-羟基-2-甲基-9,10-蒽醌(1)、1,4-二羟基-2-甲基蒽醌(2)、棕榈酸(3)、三糖酸(4)、ω-羟基木瓜碱(5)、熊果酸(6)、齐ole果酸(7)、红内酯(8)、β-谷甾醇(9)、堇青花醇(10)、1,3-二羟基-2-乙氧基甲基-9,10-蒽醌(11)。ω-Hydroxypachybasin为首次从鲁柏属植物中分离得到。1,4-二羟基-2-甲基蒽醌、红内酯和1,3-二羟基-2-乙氧基甲基-9,10-蒽醌均能显著缩短体外血浆钙包覆时间，具有促凝活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Future Foods

CiteScore

5.80

自引率

0.00%

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