Genomic insights into secondary metabolites of pharmaceutical utility for Hyphococcus flavus MCCC 1K03223T, isolated from bathypelagic seawater

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-06-01 DOI:10.1016/j.margen.2023.101031

Jin-Cheng Rong, Li Sheng, Li-Hua Jiang, Mao-Li Yi, Jin-Ying Wu, Qi Zhao

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引用次数: 1

Abstract

During an attempt to screen secondary metabolites of pharmaceutical utility, we sequenced the complete genome of type strain of a novel marine bacterial genus, named genus Hyphococcus. The type strain, Hyphococcus flavus MCCC 1K03223^T, was isolated from bathypelagic seawater of South China Sea at a depth of 2500 m. The complete genome of strain MCCC 1K03223^T is composed of a circular chromosome of 3,472,649 bp with a mean G + C content of 54.8%. Functional genomic analysis showed that this genome encodes five biosynthetic gene clusters, which were annotated to synthesize medicinally important secondary metabolites. Secondary metabolites annotated include ectoine which acts cytoprotection, ravidomycin which is an antitumor antibiotic and three other different metabolites of terpene type. The secondary metabolic potentials of H. flavus revealed in this study provide more evidences on mining bioactive substances from marine bathypelagic microorganisms.

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从深海海水中分离的黄球藻MCCC 1K03223T药用次级代谢产物的基因组学研究

在筛选药用次级代谢产物的过程中，我们对一个新的海洋细菌属Hyphoccus属的模式菌株的全基因组进行了测序。黄Hyphoccus flavus MCCC 1K03223T型菌株是从2500米深的南海半深海海水中分离得到的。菌株MCCC 1K03223T的全基因组由一条3472649bp的环状染色体组成，平均G+C含量为54.8%。功能基因组分析表明，该基因组编码5个生物合成基因簇，这些基因簇被注释为合成医学上重要的次生代谢产物。注释的次级代谢产物包括具有细胞保护作用的外泌碱、抗肿瘤抗生素雷维多霉素和其他三种不同的萜烯型代谢产物。本研究揭示的黄曲霉的次生代谢潜力为从海洋深海微生物中挖掘生物活性物质提供了更多的证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.