Delayed-onset posttraumatic stress disorder with response to methylphenidate

Q4 Medicine

Psiquiatria Biologica Pub Date : 2023-05-01 DOI:10.1016/j.psiq.2023.100397

María-José Alvarez , Ricardo López-Escribano , Ana Marzán , Luis Alonso-Alvarez

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引用次数: 0

Abstract

Introduction

Posttraumatic stress disorder (PTSD) is extremely frequent in war veterans and has been widely studied. However, the efficacy of currently available pharmacological and psychotherapeutic treatments of war PTSD and other causes of PTSD is very limited.

Method

We present a case of war PTSD with delayed expression, with a good response to complementation with methylphenidate after a failed treatment with venlafaxine and risperidone.

Results

We review the role of dopamine in the pathophysiology of PTSD and the scarce studies in the treatment of PTSD with dopaminergic drugs that show an improvement in re-experimentation and in affective symptoms, especially anhedonia and cognitive impairment.

Conclusions

We conclude that the use of methylphenidate and other dopaminergic drugs can be a promising treatment for PTSD, a high prevalent disease with a high resistance to treatment, for which we encourage the use of large sample studies.

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迟发性创伤后应激障碍伴哌甲酯反应

创伤后应激障碍（PTSD）在退伍军人中极为常见，已被广泛研究。然而，目前可用的药物和心理治疗对战争创伤后应激障碍和其他原因的疗效非常有限。方法我们报告了一例战争创伤后应激障碍，在文拉法辛和利培酮治疗失败后，表达延迟，对哌甲酯互补反应良好。结果我们回顾了多巴胺在PTSD病理生理学中的作用，以及多巴胺能药物治疗PTSD的罕见研究，这些研究表明，再实验和情感症状，特别是快感缺乏和认知障碍，都有所改善。结论我们的结论是，使用哌甲酯和其他多巴胺能药物可以很有前途地治疗创伤后应激障碍，这是一种高流行性疾病，对治疗有很高的耐药性，因此我们鼓励使用大样本研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psiquiatria Biologica Medicine-Psychiatry and Mental Health

CiteScore

0.40

自引率

0.00%

发文量

期刊介绍： Es la Publicación Oficial de la Sociedad Española de Psiquiatría Biológica. Los recientes avances en el conocimiento de la bioquímica y de la fisiología cerebrales y el progreso en general en el campo de las neurociencias han abierto el camino al desarrollo de la psiquiatría biológica, fundada sobre bases anatomofisiológicas, más sólidas y científicas que la psiquiatría tradicional.