Potential genotoxic and biological effects of 1,4 dioxane on different model organisms

IF 6.7 Q1 ENVIRONMENTAL SCIENCES

Current Opinion in Environmental Science and Health Pub Date : 2023-10-01 DOI:10.1016/j.coesh.2023.100502

Fatma Turna Demir, Eşref Demir

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Abstract

A suspected human carcinogen, the compound 1,4-dioxane (DXN) has been commonly employed as a solvent in the production of various cleaning applications, cosmetics, dyes, varnishes, waxes, and detergents. Leaked from wastewater treatment plants into surface waters, DXN may contaminate drinking water. Research into toxicity/genotoxicity of various compounds has been recognizing merits of Drosophila melanogaster on account of its short life span and genetic tractability. Therefore, this mini review attempts to revisit our current understanding of toxic and genotoxic impacts of DXN exposure and potential underlying mechanisms based on the latest in vivo studies in the field. We also aim to encourage future research to use Drosophila as a model organism to assess biological impacts of DXN and other chemicals at various levels including cellular (genotoxicity and reactive oxygen species detection in hemocytes), chromosomal (the wing spot test), behavioral (locomotor and thermal sensitivity), and developmental (abnormal anatomical endpoints).

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1,4-二恶烷对不同模式生物的潜在遗传毒性和生物效应

化合物1,4-二恶烷（DXN）是一种疑似人类致癌物，通常用作各种清洁应用、化妆品、染料、清漆、蜡和洗涤剂的生产中的溶剂。DXN从污水处理厂泄漏到地表水中，可能会污染饮用水。对各种化合物的毒性/遗传毒性的研究已经认识到黑腹果蝇由于其寿命短和遗传易处理性的优点。因此，这篇小型综述试图根据该领域的最新体内研究，重新审视我们目前对DXN暴露的毒性和遗传毒性影响以及潜在潜在潜在机制的理解。我们还旨在鼓励未来的研究将果蝇作为模型生物，在不同水平上评估DXN和其他化学物质的生物影响，包括细胞（遗传毒性和血细胞中活性氧的检测）、染色体（翼点测试）、行为（运动和热敏性）和发育（异常解剖终点）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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