Relationship among dietary intake of vitamin D, magnesium, and calcium, 25-hydroxyvitamin D levels, and glycemic control markers in individuals with type 2 diabetes

IF 1.9 Q3 ENDOCRINOLOGY & METABOLISM
Ramara Kadija Fonseca Santos , Vivianne de Sousa Rocha , Juliana de Souza Oliveira , Gabrielli Barbosa de Carvalho , Aline Rocha Reis , Cynthia Batista Santos , Beatriz da Cruz Santos , Paula Nascimento Brandão-Lima , Cinthia Fontes da Silva Santos , Liliane Viana Pires
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引用次数: 0

Abstract

Aims

To investigate the associations of 25-hydroxyvitamin D (25(OH)D) concentrations, vitamin D intake, magnesium, and calcium with glycemic control in individuals with type 2 diabetes mellitus (T2DM).

Methods

A total of 107 adult with T2DM, residing in the state of Sergipe/Brazil (latitude: 10°), were evaluated for serum concentrations of 25(OH)D, parathyroid hormone, fasting glucose, %HbA1c, insulin, C-peptide, total cholesterol and fractions, homeostasis of beta-cell function (HOMA-B), insulin sensitivity (HOMA-S) and resistance (HOMA-IR), anthropometry, body composition, and usual food intake. The results were analyzed according to 25(OH)D status (insufficient/deficient <30 ng/mL; adequate ≥30 ng/mL). Mann–Whitney, chi-square, and binary logistic regression tests were performed. P-value<0.05 was considered significant.

Results

The median age and time to T2DM diagnosis were 49 and 5 years, respectively. High inadequacy was observed in the dietary intake of vitamin D, magnesium, and calcium. Higher HOMA-B values were observed in the vitamin D adequate group (p = 0.032) and higher fasting serum glucose concentrations (p = 0.012) and %body fat (p = 0.048) in the insufficient/deficient group, which had a higher chance of elevated serum glucose (odds ratio [OR]:2.937; p = 0.020) and HOMA-IR (OR:2.496; p = 0.045).

Conclusion

Vitamin D deficiency is associated with poor glycemic control and insulin resistance, and these aspects are unrelated to inadequate dietary intake of vitamin D, magnesium, and calcium.

2型糖尿病患者膳食中维生素D、镁和钙的摄入量、25-羟基维生素D水平与血糖控制标志物的关系
目的研究2型糖尿病(T2DM)患者25-羟基维生素D(25(OH)D)浓度、维生素D摄入量、镁和钙与血糖控制的关系。方法对107名居住在巴西塞尔希培州(纬度:10°)的2型糖尿病成人进行血清25(OH)D、甲状旁腺激素、空腹血糖、%HbA1c、胰岛素、C肽、总胆固醇和组分、β细胞功能稳态(HOMA-B)、胰岛素敏感性(HOMA-S)和抵抗力(HOMA-IR)、人体测量、身体成分、,以及日常食物摄入。根据25(OH)D状态(不足/不足<;30 ng/mL;充足≥30 ng/mL)分析结果。进行Mann-Whitney、卡方和二元逻辑回归检验。P值<;0.05被认为是显著的。结果诊断为T2DM的中位年龄和时间分别为49岁和5岁。观察到维生素D、镁和钙的饮食摄入严重不足。在维生素D充足组中观察到较高的HOMA-B值(p=0.032),而在维生素D不足/缺乏组中则观察到更高的空腹血糖浓度(p=0.012)和体脂%(p=0.048),其血糖升高的几率更高(比值比[OR]:2.937;p=0.020)和HOMA-IR(比值比:2.496;p=0.045)。结论维生素D缺乏与血糖控制不佳和胰岛素抵抗有关,这些方面与维生素D、镁和钙的饮食摄入不足无关。
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来源期刊
Human Nutrition and Metabolism
Human Nutrition and Metabolism Agricultural and Biological Sciences-Food Science
CiteScore
1.50
自引率
0.00%
发文量
30
审稿时长
188 days
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