Eris - another brick in the wall: Empirical formulas, molar masses, biosynthesis reactions, enthalpy, entropy and Gibbs energy of Omicron EG.5 Eris and EG.5.1 variants of SARS-CoV-2

IF 3 4区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Microbial Risk Analysis Pub Date : 2023-10-18 DOI:10.1016/j.mran.2023.100280

Marko E. Popović , Marijana Pantović Pavlović , Marta Popović

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引用次数: 0

Abstract

Since 2019, when it appeared in Wuhan, in the wild type form later labeled Hu-1, SARS-CoV-2 mutated dozens of times and evolved towards increase in infectivity and decrease or maintenance of constant pathogenicity through dozens of variants. The last of them are Omicron EG.5 and EG.5.1. Until 2019, an empirical formula was known only for the poliovirus. Until now empirical formulas and thermodynamic properties were reported for all variants of SARS-CoV-2 and some other viruses. Also, models were developed that describe the biothermodynamic background of SARS-CoV-2 interaction with its human host. With every new mutation in SARS-CoV-2, the question is raised about the further evolution of the virus. This paper reports for the first time empirical formulas and molar masses of Omicron EG.5 and EG.5.1 variants, as well as thermodynamic properties (enthalpy, entropy and Gibbs energy) of formation and biosynthesis. Moreover, the driving force of virus multiplication was analyzed, as well as multiplication rate and pathogenicity of Omicron EG.5 and EG.5.1.

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Eris-墙上的另一块砖：奥密克戎EG.5的经验公式、摩尔质量、生物合成反应、焓、熵和吉布斯能严重急性呼吸系统综合征冠状病毒2型的Eris和EG.5.1变体

自2019年在武汉出现以来，严重急性呼吸系统综合征冠状病毒2型以后来被标记为Hu-1的野生型形式发生了数十次变异，并通过数十种变异朝着增加传染性、降低或保持恒定致病性的方向进化。最后一个是奥密克戎EG.5和EG.5.1。直到2019年，人们只知道脊髓灰质炎病毒的经验公式。迄今为止，已经报道了严重急性呼吸系统综合征冠状病毒2型和其他一些病毒的所有变体的经验公式和热力学性质。此外，还开发了描述严重急性呼吸系统综合征冠状病毒2型与其人类宿主相互作用的生物热力学背景的模型。随着严重急性呼吸系统综合征冠状病毒2型的每一次新突变，人们都对病毒的进一步进化提出了疑问。本文首次报道了奥密克戎EG.5和EG.5.1变体的经验公式和摩尔质量，以及形成和生物合成的热力学性质（焓、熵和吉布斯能）。此外，还分析了病毒繁殖的驱动力，以及奥密克戎EG.5和EG.5.1的繁殖率和致病性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microbial Risk Analysis Medicine-Microbiology (medical)

CiteScore

5.70

自引率

7.10%

发文量

审稿时长

52 days

期刊介绍： The journal Microbial Risk Analysis accepts articles dealing with the study of risk analysis applied to microbial hazards. Manuscripts should at least cover any of the components of risk assessment (risk characterization, exposure assessment, etc.), risk management and/or risk communication in any microbiology field (clinical, environmental, food, veterinary, etc.). This journal also accepts article dealing with predictive microbiology, quantitative microbial ecology, mathematical modeling, risk studies applied to microbial ecology, quantitative microbiology for epidemiological studies, statistical methods applied to microbiology, and laws and regulatory policies aimed at lessening the risk of microbial hazards. Work focusing on risk studies of viruses, parasites, microbial toxins, antimicrobial resistant organisms, genetically modified organisms (GMOs), and recombinant DNA products are also acceptable.