Therapeutic Potentials and Candidates for COVID-19

IF 1.4 4区综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES

Iranian Journal of Science and Technology, Transactions A: Science Pub Date : 2023-07-17 DOI:10.1007/s40995-023-01488-6

Mina Rezghi Rami, Maryam Meskini, Nahid Rezaei Khozani, Shayan Forouzandehdel, Saeideh Momtaz, Soumya Ghosh, Nima Rezaei, Amir Hossein Abdolghaffari

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引用次数: 0

Abstract

The current coronavirus disease 2019 (COVID-19) outbreak spread rapidly worldwide. Yet, there is no identifiable antiviral treatment, so an effective drug is urgently needed. Preventive strategies and oxygen therapy are the main practical approaches to prevent and treat COVID-19. Clinical trials are in progress for the antiviral and immunomodulation agents that eventually are being developed for COVID-19 treatment. Pharmacological, immunotherapies, natural-based supplements, biologics, and combination therapies interventions have been established. The concept of drug repurposing was re-visited, and many conventional antivirals or immunosuppresses were evaluated for Efficacy against COVID-19 infection. Even though much has been published, the rapid progression of therapeutic strategies and unpredictable disease alterations necessitates continual information updates. This review defines drug repurposing and summarizes a medication developed for other therapeutic approaches rather than SARS-CoV-2 treatment. Furthermore, we provide data on the effectiveness of traditional Chinese medicines (TCM) on COVID-19. Additionally, biological and advanced Nano-based drug delivery systems are reviewed.

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COVID-19的治疗潜力和候选药物

当前的2019冠状病毒病(COVID-19)疫情在全球迅速蔓延。然而，目前还没有明确的抗病毒治疗方法，因此迫切需要一种有效的药物。预防策略和氧疗是预防和治疗COVID-19的主要实用方法。抗病毒和免疫调节剂的临床试验正在进行中，最终将用于治疗COVID-19。药理学、免疫疗法、天然补充剂、生物制剂和联合疗法干预措施已经建立。重新审视了药物再利用的概念，并评估了许多常规抗病毒药物或免疫抑制剂对COVID-19感染的疗效。尽管已经发表了很多，但治疗策略的快速发展和不可预测的疾病变化需要不断更新信息。本综述定义了药物再利用，并总结了为其他治疗方法而不是SARS-CoV-2治疗开发的药物。此外，我们还提供了中药治疗COVID-19的有效性数据。此外，生物和先进的纳米药物传递系统进行了综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Iranian Journal of Science and Technology, Transactions A: Science MULTIDISCIPLINARY SCIENCES-

CiteScore

4.00

自引率

5.90%

发文量

122

审稿时长

>12 weeks

期刊介绍： The aim of this journal is to foster the growth of scientific research among Iranian scientists and to provide a medium which brings the fruits of their research to the attention of the world’s scientific community. The journal publishes original research findings – which may be theoretical, experimental or both - reviews, techniques, and comments spanning all subjects in the field of basic sciences, including Physics, Chemistry, Mathematics, Statistics, Biology and Earth Sciences