Oral metastasis of a human chorionic gonadotrophin secreting primary hepatic carcinoma

Q3 Dentistry

Oral and Maxillofacial Surgery Cases Pub Date : 2023-09-01 DOI:10.1016/j.omsc.2023.100321

Zilefac Brian Ngokwe , Ntep Ntep David Bienvenue , Endalle Ewoudou Catherine , Nokam Kamdem Stephane , Mandeng Chanelle Valérie , Mballa Amougou Jean Claude

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Abstract

Primary hepatic carcinomas are a leading cause of cancer deaths worldwide and more so, an important cause in women. Metastases from hepatic carcinomas to the oral cavity are rare. However, those reported are usually the first manifestation of the tumor.

We report a case of an oral metastasis from a primary hepatic carcinoma to a rare maxillary location including the hard palate presenting as a manifestation of the disease in a 48-year-old woman with elevated urine β-hCG. A biopsy of the oral lesion revealed nests of epithelial cells with hyperchromatic nuclei suggestive of metastatic hepatocellular carcinoma.

A possible route for this metastasis is the Batson's venous plexus. The prognosis after the appearance of oral metastases is usually poor as was observed with the demise of our patient about 12 weeks after the apparition of the oral mass. A multidisciplinary approach towards patients will help in early diagnosis, treatment and reduce morbidities and mortalities associated with this rare pathology.

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人绒毛膜分泌促性腺激素的原发性肝癌的口腔转移

原发性肝癌是全球癌症死亡的主要原因，尤其是女性的重要原因。肝癌转移到口腔是罕见的。然而，这些报道通常是肿瘤的第一表现。我们报告了一例从原发性肝癌到罕见上颌位置（包括硬腭）的口腔转移病例，该病例是一名48岁女性尿β-hCG升高的疾病表现。口腔病变的活检显示上皮细胞巢，细胞核深染，提示转移性肝细胞癌。这种转移的可能途径是巴特森静脉丛。口腔转移瘤出现后的预后通常很差，正如我们的患者在口腔肿块出现后约12周死亡时所观察到的那样。对患者采取多学科的方法将有助于早期诊断、治疗，并降低与这种罕见病理相关的发病率和死亡率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral and Maxillofacial Surgery Cases Medicine-Otorhinolaryngology

CiteScore

0.60

自引率

0.00%

发文量

审稿时长

69 days

期刊介绍： Oral and Maxillofacial Surgery Cases is a surgical journal dedicated to publishing case reports and case series only which must be original, educational, rare conditions or findings, or clinically interesting to an international audience of surgeons and clinicians. Case series can be prospective or retrospective and examine the outcomes of management or mechanisms in more than one patient. Case reports may include new or modified methodology and treatment, uncommon findings, and mechanisms. All case reports and case series will be peer reviewed for acceptance for publication in the Journal.