Fabricated technology of biomedical micro-nano hydrogel

Biomedical Technology Pub Date : 2023-06-01 DOI:10.1016/j.bmt.2022.11.012

Shu Yang , Fan Wang , Huijie Han , Hélder A. Santos , Yu Zhang , Hongbo Zhang , Jie Wei , Zhengwei Cai

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引用次数: 8

Abstract

Micro-nano hydrogel is a novel functional material that has attracted extensive attention in various fields. Due to the size of micron and nano level, high water content and high specific surface area, the micro-nano hydrogels can achieve minimally invasive repair and are considered as promising agents in tissue repair engineering. In this review, we summarize the design and development of micro-nano hydrogels for biomedical applications, first introduce biopolymers for the synthesis of hydrogels, then introduce the preparation technologies of microgels and nanogels respectively, and systematically summarize the application characteristics and forms of different preparation technologies. Finally, the latest application progresses of microgels in local drug delivery, bone tissue repair, soft tissue repair and immunomodulation are introduced in detail, as well as the latest application progress of nanohydrogels in cartilage repair, antibacterial, antitumor/cancer nerve repair and prevention and diagnosis of diseases, and the key research directions of micro-nano hydrogel preparation technologies in the future are clarified.

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生物医用微纳水凝胶制备技术

微纳水凝胶是一种新型的功能材料，在各个领域引起了广泛的关注。由于微米级和纳米级的尺寸、高含水量和高比表面积，微纳米水凝胶可以实现微创修复，被认为是组织修复工程中有前途的试剂。在这篇综述中，我们总结了用于生物医学应用的微纳水凝胶的设计和开发，首先介绍了用于水凝胶合成的生物聚合物，然后分别介绍了微凝胶和纳米凝胶的制备技术，并系统地总结了不同制备技术的应用特点和形式。最后，详细介绍了微凝胶在局部给药、骨组织修复、软组织修复和免疫调节等方面的最新应用进展，以及纳米水凝胶在软骨修复、抗菌、抗肿瘤/癌症神经修复和疾病预防与诊断等方面的应用进展，阐明了未来微纳水凝胶制备技术的关键研究方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomedical Technology

CiteScore

4.10

自引率

0.00%

发文量