Physical-cognitive training with dietary intervention to improve cognitive function and circulating biomarkers in postmenopausal women with obesity: Study protocol for a randomized controlled trial
{"title":"Physical-cognitive training with dietary intervention to improve cognitive function and circulating biomarkers in postmenopausal women with obesity: Study protocol for a randomized controlled trial","authors":"Puntarik Keawtep , Wanachaporn Wichayanrat , Sirinun Boripuntakul , Siriporn C. Chattipakorn , Puangsoi Worakul , Somporn Sungkarat","doi":"10.1016/j.aimed.2023.02.004","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p><span>Obesity and estrogen deprivation are significant risk factors for dementia. Dietary intervention, a cornerstone of obesity management, has shown promising effects on improving cognitive function in obese individuals. A growing body of evidence has revealed that physical activity, particularly the combined physical-cognitive exercise, has beneficial effects on cognition, metabolic and cardiovascular profiles of adults with </span>metabolic syndrome<span><span> and postmenopausal women. Given the positive effects of both dietary and exercise interventions on cognition, it is posited that the combined intervention would provide greater benefits than each intervention alone. Therefore, the present </span>randomized clinical trial will be conducted to evaluate the effects of combined physical-cognitive and dietary intervention on both cognitive function and circulating biomarkers of postmenopausal women with obesity.</span></p></div><div><h3>Methods</h3><p>A four-arm randomized controlled trial<span><span> with blinded assessor will be conducted. Ninety-two participants with postmenopausal obese women will be randomly divided into one of four groups: dietary intervention group, physical-cognitive intervention group, physical-cognitive and dietary intervention group, or control group. Participants in the three intervention groups will receive a 12-week home-based program, while those in the control group will maintain and continue their caloric intake and usual activities. The main outcomes will be executive functions, </span>episodic memory, and brain-derived neurotrophic factor (BDNF) level. All outcomes will be assessed at pre-and post-12-week intervention.</span></p></div><div><h3>Discussion</h3><p>Research evidence has established the benefits of physical-cognitive training and dietary intervention on cognition. It is expected that the combined physical-cognitive and dietary intervention may further exhibit synergistic effects on cognition beyond the results of either physical-cognitive or dietary intervention alone.</p></div><div><h3>Trial registration</h3><p>This study was registered at ClinicalTrials.gov (NCT04768725).</p></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in integrative medicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S221295882300006X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Background
Obesity and estrogen deprivation are significant risk factors for dementia. Dietary intervention, a cornerstone of obesity management, has shown promising effects on improving cognitive function in obese individuals. A growing body of evidence has revealed that physical activity, particularly the combined physical-cognitive exercise, has beneficial effects on cognition, metabolic and cardiovascular profiles of adults with metabolic syndrome and postmenopausal women. Given the positive effects of both dietary and exercise interventions on cognition, it is posited that the combined intervention would provide greater benefits than each intervention alone. Therefore, the present randomized clinical trial will be conducted to evaluate the effects of combined physical-cognitive and dietary intervention on both cognitive function and circulating biomarkers of postmenopausal women with obesity.
Methods
A four-arm randomized controlled trial with blinded assessor will be conducted. Ninety-two participants with postmenopausal obese women will be randomly divided into one of four groups: dietary intervention group, physical-cognitive intervention group, physical-cognitive and dietary intervention group, or control group. Participants in the three intervention groups will receive a 12-week home-based program, while those in the control group will maintain and continue their caloric intake and usual activities. The main outcomes will be executive functions, episodic memory, and brain-derived neurotrophic factor (BDNF) level. All outcomes will be assessed at pre-and post-12-week intervention.
Discussion
Research evidence has established the benefits of physical-cognitive training and dietary intervention on cognition. It is expected that the combined physical-cognitive and dietary intervention may further exhibit synergistic effects on cognition beyond the results of either physical-cognitive or dietary intervention alone.
Trial registration
This study was registered at ClinicalTrials.gov (NCT04768725).
期刊介绍：
Advances in Integrative Medicine (AIMED) is an international peer-reviewed, evidence-based research and review journal that is multi-disciplinary within the fields of Integrative and Complementary Medicine. The journal focuses on rigorous quantitative and qualitative research including systematic reviews, clinical trials and surveys, whilst also welcoming medical hypotheses and clinically-relevant articles and case studies disclosing practical learning tools for the consulting practitioner. By promoting research and practice excellence in the field, and cross collaboration between relevant practitioner groups and associations, the journal aims to advance the practice of IM, identify areas for future research, and improve patient health outcomes. International networking is encouraged through clinical innovation, the establishment of best practice and by providing opportunities for cooperation between organisations and communities.
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