Histopathological considerations of transvaginally implanted polytetrafluoroethylene mesh in human biological tissues

Continence Reports Pub Date : 2023-09-01 DOI:10.1016/j.contre.2023.100033

Tomoko Kuwata, Masaki Watanabe, Hiromi Kashihara, Chikako Kato, Masami Takeyama

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Abstract

Polypropylene (PP) has been widely used as a mesh for the surgical treatment of pelvic organ prolapse (POP). However, PPs have been shown to cause complications, including tissue invasion, chronic pain, and infection; therefore, regulatory agencies deemed PP mesh was not inappropriate for use in transvaginal pelvic floor reconstruction surgery, which led to a recall of mesh products. In Japan, transvaginal mesh (TVM) surgery is still being performed using ORIHIME®, a Japanese mesh made of polytetrafluoroethylene (PTFE), which has been available since 2017. In this study, we performed each histopathological examination of tissue fragments collected from recurrent cases of TVM surgery using PP and PTFE meshes. Histopathological findings showed that PTFE had less fibrosis with the surrounding tissue than PP, and no extensive infiltrative extension of inflammatory changes was observed. These results suggest that PTFE may be one of the most suitable mesh materials for pelvic floor reconstruction.

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经阴道植入聚四氟乙烯网状物在人体生物组织中的组织病理学观察

聚丙烯（PP）已被广泛用作手术治疗盆腔器官脱垂（POP）的网状物。然而，PPs已被证明会引起并发症，包括组织侵袭、慢性疼痛和感染；因此，监管机构认为PP网片不适合用于经阴道盆底重建手术，这导致了网片产品的召回。在日本，经阴道网状物（TVM）手术仍在使用ORIHIME®进行，这是一种由聚四氟乙烯（PTFE）制成的日本网状物，自2017年以来一直可用。在这项研究中，我们使用PP和PTFE网对TVM手术复发病例中收集的组织碎片进行了每次组织病理学检查。组织病理学结果显示，PTFE与周围组织的纤维化程度低于PP，并且没有观察到炎症变化的广泛浸润性扩展。这些结果表明，聚四氟乙烯可能是最适合盆底重建的网状材料之一。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Continence Reports

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