In situ forming mesoporous polydopamine nanocomposite thermogel for combined chemo-photothermal therapy of intraocular cancer

IF 4.7 3区材料科学 Q2 CHEMISTRY, PHYSICAL

Colloid and Interface Science Communications Pub Date : 2023-05-01 DOI:10.1016/j.colcom.2023.100715

Chunwen Tao , Yate Huang , Junrong Chen , Qiaohua Peng , Kaihui Nan , Yangjun Chen

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Abstract

Intraocular cancers such as retinoblastoma and uveal melanoma will induce severe vision loss or even death. Herein, a versatile nanocomposite thermogel based on hexanoyl glycol chitosan (HGC) and mesoporous polydopamine nanoparticles (MPDA NPs) was designed for potential use as an intraocular “drug depot” for the treatment of intraocular tumors. The integrated HGC-MPDA thermogel showed reversible sol-gel transition property as well as injectable and in-situ gelation abilities. The incorporated MPDA NPs endowed the thermogel with outstanding NIR laser-based photothermal conversion ability and enabled NIR light-controlled drug release. Moreover, in vitro study revealed that drug-loaded thermogel (HGC-MPDA@DOX) with the aid of 808 nm laser irradiation possessed superior anticancer effect than any single treatment via synergistic chemo-photothermal therapy. The present study demonstrated that HGC-MPDA could serve as a multifunctional platform for sustained and NIR light-responsive intravitreal drug delivery, avoiding repetitive injection, and the localized chemo-photothermal therapy provides a promising strategy against intraocular tumors.

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原位形成介孔聚多巴胺纳米复合热凝胶用于化疗-光热联合治疗眼内癌

视网膜母细胞瘤和葡萄膜黑色素瘤等眼内癌症会导致严重的视力下降甚至死亡。本文设计了一种基于己二醇壳聚糖（HGC）和介孔聚多巴胺纳米颗粒（MPDA NPs）的多功能纳米复合热凝胶，作为治疗眼内肿瘤的眼内“药物库”。集成的HGC-MPDA热凝胶显示出可逆的溶胶-凝胶转变特性以及可注射和原位凝胶化能力。所掺入的MPDA NP赋予了热凝胶卓越的基于近红外激光的光热转换能力，并实现了近红外光控药物释放。此外，体外研究表明，载药热凝胶(HGC-MPDA@DOX)在808nm激光照射的辅助下，具有比任何单一的协同化学-光热疗法都优越的抗癌效果。本研究表明，HGC-MPDA可以作为一种多功能平台，用于持续和NIR光响应的玻璃体内药物递送，避免重复注射，而局部化疗光热疗法为对抗眼内肿瘤提供了一种很有前途的策略。

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来源期刊

Colloid and Interface Science Communications Materials Science-Materials Chemistry

CiteScore

9.40

自引率

6.70%

发文量

125

审稿时长

43 days

期刊介绍： Colloid and Interface Science Communications provides a forum for the highest visibility and rapid publication of short initial reports on new fundamental concepts, research findings, and topical applications at the forefront of the increasingly interdisciplinary area of colloid and interface science.