KRT17 serves as an oncogene biomarker of poor survival in patients with hepatocellular carcinoma

Biomedical Technology Pub Date : 2023-09-01 DOI:10.1016/j.bmt.2022.12.002

Jing-Lin Wang , Lu Zhang , Chen-Zhuo Xu , Xue-Qian Qin , Shu-Jun Liu , Bao-Jie Wen , Hao-Zhen Ren

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引用次数: 1

Abstract

Hepatocellular carcinoma (HCC) is the second leading cause of cancer death from worldwide. Thus, it is imperative to clarify valuable diagnostic and prognostic biomarkers for early-stage HCC. The expression of Keratin 17 (KRT17) has been reported to be associated with certain cancer types previously. However, its role in the development of HCC has not been fully clarified. Here, we assessed the expression of KRT17 in the cancer genome atlas liver hepatocellular carcinoma (TCGA LIHC) database and in 44 pairs of samples collected from patients with HCC. In addition, Kaplan-Meir curves were used to assess the prognostic relevance of KRT17. The essential cancer- and KRT17-related biological processes were defined through gene set enrichment analysis (GSEA). Finally, the functional association between KRT17 expression and tumor cell proliferation/survival was evaluated and the signaling pathways associated with KRT17 expression in HCC were identified. Overall, we found that increased KRT17 levels were associated with lower survival, more aggressive disease, and altered immune cell infiltration in HCC patients. KRT17 may potentially act as a prognostic biomarker in HCC.

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KRT17是肝细胞癌患者生存率低的癌基因生物标志物

肝细胞癌（HCC）是全球癌症死亡的第二大原因。因此，必须阐明早期HCC的有价值的诊断和预后生物标志物。角蛋白17（KRT17）的表达先前已被报道与某些癌症类型相关。然而，它在HCC发展中的作用尚未完全阐明。在此，我们评估了KRT17在癌症基因组图谱肝细胞癌（TCGA LIHC）数据库和从HCC患者收集的44对样本中的表达。此外，Kaplan-Meir曲线用于评估KRT17的预后相关性。通过基因集富集分析（GSEA）确定了癌症和KRT17相关的基本生物学过程。最后，评估了KRT17表达与肿瘤细胞增殖/存活之间的功能相关性，并确定了与HCC中KRT17的表达相关的信号通路。总的来说，我们发现KRT17水平的升高与HCC患者的生存率降低、疾病侵袭性更强和免疫细胞浸润改变有关。KRT17可能作为HCC的预后生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomedical Technology

CiteScore

4.10

自引率

0.00%

发文量