Association between enteric dysmotility and GnRH antibodies: A meta-analysis

Gastroenterology & Endoscopy Pub Date : 2023-10-01 DOI:10.1016/j.gande.2023.08.002

Karam R. Motawea , Noheir Ashraf Ibrahem Fathy Hassan , Nesreen Elsayed Talat , Rowan H. Elhalag , Sarya Swed , Abdulqadir J. Nashwan , Agyad Bakkour , Bisher Sawaf , Ivan Cherrez-Ojeda , Wael Hafez

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引用次数: 0

Abstract

Background and aim

Recent studies reported a significant association between enteric dysmotility and GnRH antibodies, other studies reported no significant association. Therefore, we aimed to perform a meta-analysis to investigate and clarify the exact association between enteric dysmotility and GnRH antibodies.

Methods

PubMed, Web of Science, and Scopus databases were searched. The inclusion criteria were any randomized control trials or observational studies that reported the level or prevalence of GnRH IgM or GnRH IgG antibodies in patients with enteric dysmotility matched with healthy controls. Exclusion criteria: Case reports, case series, reviews, editorials, and animal studies. RevMan software 5.4 was used to perform the meta-analysis.

Results

After search of the literature, 4 studies were included in the meta-analysis with a total number of 469 individuals included in the study. The pooled analysis showed a statistically significant association between enteric dysmotility and increased prevalence of GnRH IgM antibodies compared with controls (RR = 4.47, 95% CI = 1.17 to 17.06, p-value = 0.03). Contrarily, no statistically significant association between enteric dysmotility and the levels of IgM antibodies as well as the prevalence of IgG antibodies was found compared with controls, (MD = 0.92, 95% CI = -1.01 to 2.86, p-value = 0.35) and (RR = 1.84, 95% CI = 0.09 to 35.86, p-value = 0.69), respectively.

Conclusion

Our study detected a significant association between intestinal dysmotility and high prevalence of GnRH IgM antibodies when matched with controls. Conversely, we found no statistically significant association between enteric dysmotility and IgG antibodies. Further research is warranted to support our results and clarify the exact association between enteric dysmotility and GnRH antibodies.

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肠蠕动障碍与GnRH抗体之间的关系:一项荟萃分析

背景和目的最近的研究报告了肠道运动障碍与GnRH抗体之间的显著关联，其他研究报告没有显著关联。因此，我们旨在进行荟萃分析，以调查和阐明肠道运动障碍与GnRH抗体之间的确切关联。方法检索PubMed、Web of Science和Scopus数据库。纳入标准是任何随机对照试验或观察性研究，这些试验或研究报告了与健康对照相匹配的肠道运动障碍患者的GnRH IgM或GnRH IgG抗体水平或流行率。排除标准：病例报告、病例系列、综述、社论和动物研究。RevMan软件5.4用于进行荟萃分析。结果检索文献后，荟萃分析中包括4项研究，共有469人参与研究。合并分析显示，与对照组相比，肠道运动障碍与GnRH-IgM抗体患病率增加之间存在统计学显著相关性（RR=4.47,95%CI=1.17至17.06，p值=相反，与对照组相比，肠道运动障碍与IgM抗体水平以及IgG抗体的流行率之间没有发现统计学上显著的相关性，（MD=0.92，95%CI=-1.01至2.86，p值=0.35）和（RR=1.84，95%CI=0.09至35.86，p值=0.69）。结论我们的研究发现，与对照组相比，肠道运动障碍与GnRH-IgM抗体的高患病率之间存在显著相关性。相反，我们发现肠道运动障碍和IgG抗体之间没有统计学上的显著关联。需要进一步的研究来支持我们的结果，并阐明肠道运动障碍和GnRH抗体之间的确切联系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gastroenterology & Endoscopy

CiteScore

0.60

自引率

0.00%

发文量