Di Ma, Weihua Zhuang, Qi Liu, Jingruo Chen, Chengming Li, Shufen Li, Mao Chen
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引用次数: 0
Abstract
Hydrophobic lipid droplets (LDs)-specific fluorescent probes have shown great potential in bioimaging. However, their in vivo bioapplications are also limited by their strong hydrophobic nature. To address this issue, we prepared a novel tetraphenylethylene (TPE)-based fluorescent probe, namely, MeOTTI, and a pH-responsive polymeric micelle to establish a nanodiagnostic system for the imaging of LDs in atherosclerosis. MeOTTI demonstrated good LDs-specific imaging capability with good anti-photobleaching ability but poor water solubility. MeOTTI-encapsulated nanoparticles (MeOTTI-PMEA NPs) have shown improved water solubility and biocompatibility of MeOTTI. MeOTTI-PMEA NPs exhibited great stability at pH 7.4, while they showed good acid-responsive ability with accelerated MeOTTI release. Importantly, MeOTTI-PMEA NPs could efficiently light up the LDs in cells and in mice atherosclerosis plaques. The construction of LDs-specific probe-loaded nanodiagnostic system is expected to create enthusiasm for the development of new tools for bioimaging.
期刊介绍:
The Chemical Engineering Journal is an international research journal that invites contributions of original and novel fundamental research. It aims to provide an international platform for presenting original fundamental research, interpretative reviews, and discussions on new developments in chemical engineering. The journal welcomes papers that describe novel theory and its practical application, as well as those that demonstrate the transfer of techniques from other disciplines. It also welcomes reports on carefully conducted experimental work that is soundly interpreted. The main focus of the journal is on original and rigorous research results that have broad significance. The Catalysis section within the Chemical Engineering Journal focuses specifically on Experimental and Theoretical studies in the fields of heterogeneous catalysis, molecular catalysis, and biocatalysis. These studies have industrial impact on various sectors such as chemicals, energy, materials, foods, healthcare, and environmental protection.