The evaluation of curcumin effects on some acute phase proteins in aflatoxin B1 applied rats.

IF 0.7 4区医学 Q4 PHARMACOLOGY & PHARMACY

Pakistan journal of pharmaceutical sciences Pub Date : 2023-09-01

Deniz Uluisik, Ercan Keskin, Durmus Hatipoglu

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引用次数: 0

Abstract

This study was designed to determine the effects of curcumin on some acute phase proteins in rats treated with aflatoxin B1. In this study, healthy 38 male Wistar Albino rats were used. The animals in control group were given food and distilled water. The animals in DMSO group were orally given 1 ml 10% DMSO daily for 60 days, animals in Cur group was orally given 300mg/kg curcumin dissolved in 10% DMSO daily for 60 days. Animals in AFB1 group were orally given 250µg/kg aflatoxin B1 dissolved in 10% DMSO daily for 60 days. Animals in AFB1+Cur group was orally given 250µg/kg aflatoxin B1 dissolved in 10% DMSO and 300mg/kg curcumin dissolved in 10% DMSO daily for 60 days. In blood samples taken from all animals, fibrinogen, prothrombin, albumin and CRP levels were determined. In this study, fibrinogen, prothrombin and CRP levels with AFB1 group were found to be significantly higher than the control group (p<0.05). In the AFB1+Cur group, fibrinogen and CRP levels were lower than in the aflatoxin group (p<0.05). In the study, it was observed that albumin level in rats in AFB1 group significantly decreased compared to the control group (p<0.05) and this difference was found to be eliminated depend on the application of curcumin together with aflatoxin B1 (p<0.05). In conclusion, our findings regarding the ameliorating effects of curcumin on acute phase protein abnormalities caused by aflatoxicosis will contribute to future research.

本刊更多论文

姜黄素对黄曲霉毒素B1应用大鼠急性期某些蛋白质影响的评价。

本研究旨在确定姜黄素对黄曲霉毒素B1处理的大鼠某些急性期蛋白质的影响。在本研究中，使用了38只健康的雄性Wistar Albino大鼠。对照组动物给予食物和蒸馏水。DMSO组动物每天口服1ml 10%DMSO，持续60天，Cur组动物每天服用300mg/kg溶解在10%DMSO中的姜黄素，持续60天后。AFB1组动物每天口服溶于10%DMSO的黄曲霉毒素B1 250µg/kg，持续60天。AFB1+Cur组动物每天口服250µg/kg溶于10%DMSO的黄曲霉毒素B1和300mg/kg溶于10%DMSO的姜黄素，持续60天。在所有动物的血液样本中，测定了纤维蛋白原、凝血酶原、白蛋白和CRP水平。在本研究中，AFB1组的纤维蛋白原、凝血酶原和CRP水平显著高于对照组（p

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来源期刊

Pakistan journal of pharmaceutical sciences 医学-药学

CiteScore

1.40

自引率

12.50%

发文量

211

审稿时长

4.5 months

期刊介绍： Pakistan Journal of Pharmaceutical Sciences (PJPS) is a peer reviewed multi-disciplinary pharmaceutical sciences journal. The PJPS had its origin in 1988 from the Faculty of Pharmacy, University of Karachi as a biannual journal, frequency converted as quarterly in 2005, and now PJPS is being published as bi-monthly from January 2013. PJPS covers Biological, Pharmaceutical and Medicinal Research (Drug Delivery, Pharmacy Management, Molecular Biology, Biochemical, Pharmacology, Pharmacokinetics, Phytochemical, Bio-analytical, Therapeutics, Biotechnology and research on nano particles.