Concomitant Resistance to Cefiderocol and Ceftazidime/Avibactam in Two Carbapenemase-Producing Klebsiella pneumoniae Isolates from Two Lung Transplant Patients.

IF 2.3 4区医学 Q3 INFECTIOUS DISEASES

Microbial drug resistance Pub Date : 2024-01-01 Epub Date: 2023-10-23 DOI:10.1089/mdr.2023.0054

Greta Bellinzona, Cristina Merla, Marta Corbella, Elizabeth Nagy Iskandar, Elena Seminari, Angela Di Matteo, Stefano Gaiarsa, Greta Petazzoni, Davide Sassera, Fausto Baldanti, Aurora Piazza, Patrizia Cambieri

引用次数: 0

Abstract

In this study, we present two cases of Klebsiella pneumoniae, one KPC-33- and one NDM-1-producing, showing resistance to cefiderocol and ceftazidime/avibactam, collected in the intensive care unit of a hospital in Northern Italy from two patients who had recently undergone lung transplantation. Whole-genome sequencing was performed to investigate the molecular features of these strains.

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两名肺移植患者的两株产碳青霉烯酶的肺炎克雷伯菌分离株对头孢iderocol和头孢他啶/阿维巴坦同时耐药。

在这项研究中，我们报告了两例肺炎克雷伯菌病例，一例是KPC-33型和一例是NDM-1型，显示出对头孢iderocol和头孢他啶/阿维巴坦的耐药性，这些病例是在意大利北部一家医院的重症监护室从两名最近接受肺移植的患者身上收集的。进行全基因组测序以研究这些菌株的分子特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microbial drug resistance 医学-传染病学

CiteScore

6.00

自引率

3.80%

发文量

118

审稿时长

6-12 weeks

期刊介绍： Microbial Drug Resistance (MDR) is an international, peer-reviewed journal that covers the global spread and threat of multi-drug resistant clones of major pathogens that are widely documented in hospitals and the scientific community. The Journal addresses the serious challenges of trying to decipher the molecular mechanisms of drug resistance. MDR provides a multidisciplinary forum for peer-reviewed original publications as well as topical reviews and special reports. MDR coverage includes: Molecular biology of resistance mechanisms Virulence genes and disease Molecular epidemiology Drug design Infection control.