Relationship between Triglyceride-Glucose Index and Disease Activity and Subclinical Atherosclerosis in Rheumatoid Arthritis.

IF 1.2 Q4 RHEUMATOLOGY

Current rheumatology reviews Pub Date : 2024-01-01 DOI:10.2174/0115733971259984230922054439

Seham Abdallah Elazab, Wagenat Effat Elsayed, Nosaiba Mohammed Alrahim, Marwa Abdallah Elsaid, Samah Mohamed Akab, Alshimaa Ahmed Ezzat Mohammed Enayet, Maha Salah Eldin Mohamed, Sherien Abdallah Elazab, Marwa Mostafa Sonbol, Radwa Mohamed Fath Allah

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引用次数: 0

Abstract

Background: In rheumatoid arthritis (RA), insulin resistance (IR) is related to inflammatory markers, disease activity, and progression of atherosclerotic changes. Triglyceride-glucose (TyG) index is a relatively new indicator of IR.

Aims: The present study aimed to investigate the relationship between TyG index, disease activity and subclinical atherosclerosis (SCA) in RA patients.

Methods: The present case-control study included 100 RA patients and 50 age- and sex-matched healthy controls. All participants were subjected to careful history taking through clinical examination and standard laboratory assessment. The TyG index was calculated as TyG index = ln (Fasting triglyceride (mg/dL) × fasting glucose (mg/dL))/2. Carotid intima-media thickness (CIMT) measurement was done using B-mode ultrasound.

Results: Patients had significantly higher TyG index as compared to controls. Patients with high disease activity had significantly higher frequency of extraarticular manifestations (39.6% versus 51.6%, p = 0.028), higher Larsen score (3.8 ± 1.3 versus 2.8 ± 1.2, p < 0.001), higher anti-cyclic citrullinated peptide (anti-CCP) levels (median (IQR): 243.1 (205.0-408.0) U/ml versus 99.0 (78.0-332.5), p < 0.001), higher TyG index (4.8 ± 0.22 versus 4.67 ± 0.24, p = 0.006), and higher CIMT (0.87 ± 0.22 versus 0.77 ± 0.17 mm, p = 0.018). Patients with SCA had higher BMI (34.6 ± 6.2 versus 30.5 ± 5.3 Kg/m², p < 0.001), higher Larsen score (3.7 ± 1.4 versus 3.1 ± 1.3, p = 0.028) and higher TyG index (4.89 ± 0.23 versus 4.64 ± 0.19, p < 0.001). Binary logistic regression analysis identified patients' age (OR (95% CI): 0.94 (0.89-0.99), p = 0.018), Larsen score (OR (95% CI): 1.93 (1.32-2.82), p = <0.001), anti-CCP (OR (95%): 1.04 (1.02-1.07), p = 0.032), and TyG index (OR (95% CI): 22.67 (2.14-240.4), p = 0.01) as significant predictors of high disease activity in multivariate analysis.

Conclusion: IR estimated by the TyG index is related to disease activity and SCA in RA patients.

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甘油三酯-葡萄糖指数与类风湿性关节炎疾病活动性及亚临床动脉粥样硬化的关系。

背景：在类风湿性关节炎（RA）中，胰岛素抵抗（IR）与炎症标志物、疾病活动和动脉粥样硬化变化的进展有关。甘油三酯-葡萄糖（TyG）指数是一种相对较新的IR指标。目的：本研究旨在探讨TyG指数、疾病活动性与RA患者亚临床动脉粥样硬化（SCA）之间的关系。方法：本病例对照研究包括100名RA患者和50名年龄和性别匹配的健康对照。所有参与者都通过临床检查和标准实验室评估进行了仔细的病史记录。TyG指数计算为TyG指数=ln（空腹甘油三酯（mg/dL）×空腹血糖（mg/dL））/2。颈动脉内膜-中膜厚度（CIMT）测量采用B型超声。结果：与对照组相比，患者的TyG指数明显更高。疾病活动性高的患者关节外表现的频率明显更高（39.6%对51.6%，p=0.028），Larsen评分更高（3.8±1.3对2.8±1.2，p<0.001），抗环瓜氨酸肽（抗CCP）水平更高（中位数（IQR）：243.1（205.0-408.0）U/ml对99.0（78.0-332.5），p=0.001），TyG指数更高（4.8±0.22对4.67±0.24，p=0.006），和更高的CIMT（0.87±0.22对0.77±0.17 mm，p=0.018）。SCA患者的BMI更高（34.6±6.2对30.5±5.3 Kg/m2，p=0.001），Larsen评分更高（3.7±1.4对3.1±1.3，p=0.028），TyG指数更高（4.89±0.23对4.64±0.19，p=0.001，Larsen评分（OR（95%CI）:1.93（1.32-2.82），p=结论：TyG指数估计的IR与RA患者的疾病活动性和SCA有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current rheumatology reviews RHEUMATOLOGY-

CiteScore

2.30

自引率

0.00%

发文量

期刊介绍： Current Rheumatology Reviews publishes frontier reviews on all the latest advances on rheumatology and its related areas e.g. pharmacology, pathogenesis, epidemiology, clinical care, and therapy. The journal"s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians in rheumatology.