Cognition and nutrition: the role of dietary protein and amino acids in cognitive health.

IF 3 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Current Opinion in Clinical Nutrition and Metabolic Care Pub Date : 2024-01-01 Epub Date: 2023-10-18 DOI:10.1097/MCO.0000000000000987

Kenji Nagao

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引用次数: 0

Abstract

Purpose of review: This review underscores recent advancements in the role of protein and amino acid nutrition on cognitive health. Given the escalating prevalence of neurodegenerative disorders, particularly Alzheimer's disease, it is essential to understand nonpharmaceutical interventions that could potentially counteract their development and progression.

Recent findings: Emerging research indicates that moderate protein intake may offer protective benefits against dementia. Studies also emphasize the importance of considering not just the quantity, but also the quality and source of dietary protein. The role of essential amino acids in nutrition is gaining attention in the field of cognitive health. Moreover, plasma-free amino acid concentrations, particularly branched-chain amino acids, are being explored as potential biomarkers for cognitive health and Alzheimer's disease. Mechanistic studies suggest that proteins and amino acids help maintain neuronal integrity, reduce inflammation, and support muscle retention, all essential factors for cognitive health.

Summary: Recent findings emphasize the complex relationship between protein, amino acids, and cognitive health, highlighting the potential of dietary interventions in warding off neurodegenerative diseases. Given the observational nature of these findings, further interventional and longitudinal studies are needed to ascertain causality and elucidate the mechanisms involved.

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认知与营养：膳食蛋白质和氨基酸在认知健康中的作用。

综述的目的：这篇综述强调了蛋白质和氨基酸营养在认知健康中的作用的最新进展。鉴于神经退行性疾病，特别是阿尔茨海默病的患病率不断上升，了解可能抵消其发展和进展的非药物干预措施至关重要。最近的发现：新出现的研究表明，适量摄入蛋白质可能对痴呆症有保护作用。研究还强调，不仅要考虑膳食蛋白质的数量，还要考虑蛋白质的质量和来源。必需氨基酸在营养中的作用在认知健康领域越来越受到关注。此外，血浆游离氨基酸浓度，特别是支链氨基酸，正在被探索作为认知健康和阿尔茨海默病的潜在生物标志物。机制研究表明，蛋白质和氨基酸有助于维持神经元的完整性，减少炎症，并支持肌肉保留，所有这些都是认知健康的重要因素。摘要：最近的研究结果强调了蛋白质、氨基酸和认知健康之间的复杂关系，突出了饮食干预在预防神经退行性疾病方面的潜力。鉴于这些发现的观察性质，需要进一步的介入和纵向研究来确定因果关系并阐明所涉及的机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Clinical Nutrition and Metabolic Care 医学-内分泌学与代谢

CiteScore

5.30

自引率

6.50%

发文量

116

审稿时长

6-12 weeks

期刊介绍： A high impact review journal which boasts an international readership, Current Opinion in Clinical Nutrition and Metabolic Care offers a broad-based perspective on the most recent and exciting developments within the field of clinical nutrition and metabolic care. Published bimonthly, each issue features insightful editorials and high quality invited reviews covering two or three key disciplines which include protein, amino acid metabolism and therapy, lipid metabolism and therapy, nutrition and the intensive care unit and carbohydrates. Each discipline introduces world renowned guest editors to ensure the journal is at the forefront of knowledge development and delivers balanced, expert assessments of advances from the previous year.