U. Meza, C. Romero-Méndez, S. Sánchez-Armáss, A.A. Rodríguez-Menchaca
{"title":"Role of rafts in neurological disorders","authors":"U. Meza, C. Romero-Méndez, S. Sánchez-Armáss, A.A. Rodríguez-Menchaca","doi":"10.1016/j.nrleng.2023.10.003","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><p>Rafts are protein-lipid structural nanodomains involved in efficient signal transduction and the modulation of physiological processes of the cell plasma membrane. Raft disruption in the nervous system has been associated with a wide range of disorders.</p></div><div><h3>Development</h3><p>We review the concept of rafts, the nervous system processes in which they are involved, and their role in diseases such as Parkinson’s disease, Alzheimer disease, and Huntington disease.</p></div><div><h3>Conclusions</h3><p>Based on the available evidence, preservation and/or reconstitution of rafts is a promising treatment strategy for a wide range of neurological disorders.</p></div>","PeriodicalId":94155,"journal":{"name":"Neurologia","volume":"38 9","pages":"Pages 671-680"},"PeriodicalIF":0.0000,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2173580823000573/pdfft?md5=0d7bd1d9d9c808ac1e722bec37aea222&pid=1-s2.0-S2173580823000573-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurologia","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2173580823000573","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction
Rafts are protein-lipid structural nanodomains involved in efficient signal transduction and the modulation of physiological processes of the cell plasma membrane. Raft disruption in the nervous system has been associated with a wide range of disorders.
Development
We review the concept of rafts, the nervous system processes in which they are involved, and their role in diseases such as Parkinson’s disease, Alzheimer disease, and Huntington disease.
Conclusions
Based on the available evidence, preservation and/or reconstitution of rafts is a promising treatment strategy for a wide range of neurological disorders.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
