Efficacy of different mouthwashes against COVID-19: A systematic review and network meta-analysis

IF 5.7 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Japanese Dental Science Review Pub Date : 2023-10-11 DOI:10.1016/j.jdsr.2023.09.003

Luca Sbricoli , Lucia Schiavon , Giulia Brunello , Paola Brun , Kathrin Becker , Stefano Sivolella

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引用次数: 1

Abstract

To evaluate the effectiveness of antiseptic mouthwashes in reducing SARS-CoV-2 load clinically and in vitro. A systematic electronic search (MEDLINE/Scopus/Cochrane) was conducted to identify prospective clinical and in vitro studies published between 2019 included and 16 June 2023 assessing the effectiveness of mouthwashes in reducing SARS-CoV-2 load in saliva or surrogates. Data were summarized in tables and a network meta-analysis was performed for clinical trials. Thirty-five studies (14 RCTs, 21 in vitro) fulfilled the inclusion criteria. The risk of bias was judged to be high for 2 clinical and 7 in vitro studies. The most commonly test product was chlorhexidine alone or in combination with other active ingredients, followed by povidone-iodine, hydrogen peroxide and cetylpyridinium chloride. Overall, the descriptive analysis revealed the effectiveness of the mouthwashes in decreasing the salivary viral load both clinically and in vitro. Network meta-analysis demonstrated a high degree of heterogeneity. Among these studies, only chlorhexidine 0.20% was associated to a significant Ct increase in the saliva 5 min after rinsing compared to non-active control (p = 0.027). Data from clinical and in vitro studies suggested the antiviral efficacy of commonly used mouthwashes. Large well-balanced trials are needed to identify the best rinsing protocols.

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查看原文本刊更多论文

不同漱口水对新冠肺炎的疗效：系统综述和网络荟萃分析。

评估抗菌漱口水在临床和体外降低严重急性呼吸系统综合征冠状病毒2型负荷方面的有效性。进行了一项系统的电子搜索（MEDLINE/Scopus/Cochrane），以确定2019年至2023年6月16日期间发表的前瞻性临床和体外研究，评估漱口水在降低唾液或替代物中严重急性呼吸系统综合征冠状病毒2型载量方面的有效性。数据汇总在表格中，并对临床试验进行网络荟萃分析。35项研究（14项随机对照试验，21项体外试验）符合纳入标准。2项临床研究和7项体外研究均判定偏倚风险较高。最常见的测试产品是氯己定单独或与其他活性成分组合，其次是聚维酮碘、过氧化氢和氯化十六烷基吡啶。总体而言，描述性分析揭示了漱口水在临床和体外降低唾液病毒载量方面的有效性。网络荟萃分析显示出高度的异质性。在这些研究中，与非活性对照组相比，只有0.20%的氯己定与漱口后5分钟唾液中Ct的显著增加有关（p=0.027）。临床和体外研究的数据表明，常用漱口水具有抗病毒功效。需要进行大规模平衡试验来确定最佳冲洗方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Japanese Dental Science Review DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

9.90

自引率

1.50%

发文量

审稿时长

32 days

期刊介绍： The Japanese Dental Science Review is published by the Japanese Association for Dental Science aiming to introduce the modern aspects of the dental basic and clinical sciences in Japan, and to share and discuss the update information with foreign researchers and dentists for further development of dentistry. In principle, papers are written and submitted on the invitation of one of the Editors, although the Editors would be glad to receive suggestions. Proposals for review articles should be sent by the authors to one of the Editors by e-mail. All submitted papers are subject to the peer- refereeing process.