Abdominal aortic calcification in patients newly diagnosed with essential thrombocythemia.

IF 2.3 Q2 HEMATOLOGY

Blood Research Pub Date : 2023-12-31 Epub Date: 2023-10-19 DOI:10.5045/br.2023.2023125

Myung-Won Lee, Jeong Suk Koh, Sora Kang, Hyewon Ryu, Ik-Chan Song, Hyo-Jin Lee, Hwan-Jung Yun, Seon Young Kim, Seong Soo Kim, Deog-Yeon Jo

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引用次数: 0

Abstract

Background: Although atherosclerosis is likely to be involved in the development of arterial thrombotic events in patients with essential thrombocythemia (ET), abdominal aortic calcification (AAC) has rarely been investigated. We evaluated the prevalence and clinical relevance of AAC at the time of ET diagnosis.

Methods: This retrospective study included patients newly diagnosed with ET who underwent abdominal computed tomography (CT) at the time of diagnosis between January 2002 and December 2021 at Chungnam National University Hospital, Daejeon, Korea. CT images were reviewed and an aortic calcification score was assigned.

Results: Of the 94 patients (median age, 62 yr; range, 18‒90 yr), AAC was detected in 62 (66.0%). AAC was most commonly mild (33.0%), followed by moderate (22.7%) and severe (5.3%). Old age [odds ratio (OR), 34.37; 95% confidence interval (CI), 12.32‒95.91; P＜0.001] was an independent risk factor for AAC. The patients with AAC had a higher WBC count (11.8±4.7 vs. 9.7±2.9×10⁹/L, P=0.017), higher neutrophil-to-lymphocyte ratio (4.3±2.7 vs. 3.1±1.5, P=0.039), and higher JAK2V617F positivity (81.5% vs. 58.8%, P=0.020) compared to those without AAC. AAC was an independent risk factor for arterial thrombotic vascular events that occurred before or at diagnosis of ET (OR, 4.12; 95% CI, 1.11‒15.85; P=0.034).

Conclusion: AAC is common in patients with ET and is associated with arterial thrombotic events.

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新诊断为原发性血小板增多症患者的腹主动脉钙化。

背景：尽管动脉粥样硬化可能与原发性血小板增多症（ET）患者动脉血栓事件的发生有关，但腹主动脉钙化（AAC）很少被研究。我们评估了在ET诊断时AAC的患病率和临床相关性。方法：本回顾性研究包括2002年1月至2021年12月在韩国大田忠南国立大学医院接受腹部计算机断层扫描（CT）诊断的新诊断为ET的患者。对CT图像进行复查，并对主动脉钙化进行评分。结果：在94例患者中（中位年龄62岁；范围18-90岁），AAC检出率为62例（66.0%）。AAC最常见的是轻度（33.0%），其次是中度（22.7%）和重度（5.3%）。老年[比值比（OR）=34.37，95%置信区间（CI）=12.32-95.91，P9/L，P=0.017），中性粒细胞与淋巴细胞的比值较高（4.3±2.7 vs.3.1±1.5，P=0.039），JAK2V617F阳性率较高（81.5%vs.58.8%，P=0.020）与没有AAC的那些相比。AAC是ET诊断前或诊断时发生动脉血栓性血管事件的独立危险因素（or=4.12，95%CI=1.11-15.85，P=0.034）。结论：AAC在ET患者中常见，与动脉血栓性事件有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Blood Research HEMATOLOGY-

CiteScore

3.70

自引率

0.00%

发文量