Cough and swallow after laparotomy in anesthetized cats

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-10-17 DOI:10.1016/j.resp.2023.104179

Ivan Poliacek , Lukas Martvon , Michal Simera , Marcel Veternik , Jakub Misek , Lucia Cibulkova , Kimberly E. Iceman , Donald C. Bolser , Teresa Pitts

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Abstract

An anesthetized cat animal model was used to evaluate changes in cough and swallow after a small midline upper abdominal incision (laparotomy). Two additional conditions were tested: sealing the laparotomy with gentle suctioning via a small cannula, and subsequent closure of the abdominal wall with suture. These abdominal wall manipulations resulted in no changes in the cough reflex, but produced higher motor drive to pharyngeal musculature (thyropharyngeus and geniohyoid muscles) during swallow. Swallow-breathing coordination phase preference shifted towards swallow occurring more during the inspiratory phase. There were no significant changes in cough motor pattern, or cough and swallow number and temporal features. The respiratory changes were limited to reduced inspiratory motor drive to the diaphragm. The results are consistent with an important role of sensory feedback from the abdominal wall in regulation of swallow motor pattern. The level of reflex modulation may depend on the extent of injury and likely on its position in the abdomen.

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麻醉猫剖腹手术后咳嗽和吞咽。

使用麻醉猫动物模型来评估上腹部中线小切口（剖腹手术）后咳嗽和吞咽的变化。测试了两种额外的条件：通过小套管轻轻抽吸来密封剖腹手术，然后用缝线缝合腹壁。这些腹壁操作没有导致咳嗽反射的变化，但在吞咽过程中对咽部肌肉组织（甲状腺咽肌和颏舌肌）产生了更高的运动驱动力。吞咽呼吸协调阶段偏好向吞咽转移，在吸气阶段发生更多。咳嗽运动模式、咳嗽吞咽次数和时间特征没有显著变化。呼吸系统的变化仅限于膈肌的吸气运动驱动减少。结果与腹壁感觉反馈在调节吞咽运动模式中的重要作用一致。反射调节的水平可能取决于损伤的程度，也可能取决于其在腹部的位置。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.