MicroRNA‑mediated regulation in lung adenocarcinoma: Signaling pathways and potential therapeutic implications (Review).

IF 3.8 3区医学 Q2 ONCOLOGY

Oncology reports Pub Date : 2023-12-01 Epub Date: 2023-10-20 DOI:10.3892/or.2023.8648

Jiye Liu, Fei Zhang, Jiahe Wang, Yibing Wang

{"title":"MicroRNA‑mediated regulation in lung adenocarcinoma: Signaling pathways and potential therapeutic implications (Review).","authors":"Jiye Liu, Fei Zhang, Jiahe Wang, Yibing Wang","doi":"10.3892/or.2023.8648","DOIUrl":null,"url":null,"abstract":"<p><p>Lung adenocarcinoma (LUAD) poses a significant global health burden owing to its high incidence rate and unfavorable prognosis, driven by frequent recurrence and drug resistance. Understanding the biological mechanisms underlying LUAD is imperative to developing advanced therapeutic strategies. Recent research has highlighted the role of dysregulated microRNAs (miRNAs) in LUAD progression through diverse signaling pathways, including the Wnt and AKT pathways. Of particular interest is the novel pathological mechanism involving the interaction between competing endogenous RNAs (ceRNAs) and miRNAs. This review critically analyzed the impact of aberrant miRNA expression on LUAD development, shedding light on the associated signaling pathways. It also highlighted the emerging significance of ceRNA‑miRNA interactions in LUAD pathogenesis. Elucidating the intricate regulatory networks involving miRNAs and ceRNAs presents a promising avenue for the development of potential therapeutic interventions and diagnostic biomarkers in LUAD. Further research in this area is essential to advance precision medicine approaches and improve patient outcomes.</p>","PeriodicalId":19527,"journal":{"name":"Oncology reports","volume":"50 6","pages":""},"PeriodicalIF":3.8000,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/35/33/or-50-06-08648.PMC10603552.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oncology reports","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3892/or.2023.8648","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/10/20 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Lung adenocarcinoma (LUAD) poses a significant global health burden owing to its high incidence rate and unfavorable prognosis, driven by frequent recurrence and drug resistance. Understanding the biological mechanisms underlying LUAD is imperative to developing advanced therapeutic strategies. Recent research has highlighted the role of dysregulated microRNAs (miRNAs) in LUAD progression through diverse signaling pathways, including the Wnt and AKT pathways. Of particular interest is the novel pathological mechanism involving the interaction between competing endogenous RNAs (ceRNAs) and miRNAs. This review critically analyzed the impact of aberrant miRNA expression on LUAD development, shedding light on the associated signaling pathways. It also highlighted the emerging significance of ceRNA‑miRNA interactions in LUAD pathogenesis. Elucidating the intricate regulatory networks involving miRNAs and ceRNAs presents a promising avenue for the development of potential therapeutic interventions and diagnostic biomarkers in LUAD. Further research in this area is essential to advance precision medicine approaches and improve patient outcomes.

Abstract Image

查看原文本刊更多论文

肺腺癌中微小RNA介导的调节：信号通路和潜在的治疗意义（综述）。

肺腺癌（LUAD）由于其高发病率和不良预后，以及频繁复发和耐药性，对全球健康造成了重大负担。了解LUAD的生物学机制对于开发先进的治疗策略至关重要。最近的研究强调了失调的微小RNA（miRNA）通过多种信号通路（包括Wnt和AKT通路）在LUAD进展中的作用。特别令人感兴趣的是涉及竞争性内源性RNA（ceRNA）和miRNA之间相互作用的新的病理机制。这篇综述批判性地分析了miRNA异常表达对LUAD发展的影响，揭示了相关的信号通路。它还强调了ceRNA-miRNA相互作用在LUAD发病机制中的新意义。阐明涉及miRNA和ceRNA的复杂调控网络为开发LUAD的潜在治疗干预和诊断生物标志物提供了一条有希望的途径。这一领域的进一步研究对于推进精准医学方法和改善患者预后至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Oncology reports 医学-肿瘤学

CiteScore

8.50

自引率

2.40%

发文量

187

审稿时长

3 months

期刊介绍： Oncology Reports is a monthly, peer-reviewed journal devoted to the publication of high quality original studies and reviews concerning a broad and comprehensive view of fundamental and applied research in oncology, focusing on carcinogenesis, metastasis and epidemiology.