Edgar Carnero Contentti, Pablo A Lopez, Juan Pablo Pettinicchi, Juan Criniti, Agustín Pappolla, Jimena Miguez, Edgardo Cristiano, Liliana Patrucco, Susana Liwacki, Verónica Tkachuk, María E Balbuena, Carlos Vrech, Norma Deri, Jorge Correale, Mariano Marrodan, María C Ysrraelit, Felisa Leguizamon, Geraldine Luetic, María L Menichini, Darío Tavolini, Carolina Mainella, Gisela Zanga, Marcos Burgos, Javier Hryb, Andrés Barboza, Luciana Lazaro, Ricardo Alonso, Nora Fernández Liguori, Débora Nadur, Marina Alonso Serena, Alejandro Caride, Friedemann Paul, Juan I Rojas
{"title":"Mortality of neuromyelitis optica spectrum disorder patients in an Argentinean population: A study from the RelevarEM registry.","authors":"Edgar Carnero Contentti, Pablo A Lopez, Juan Pablo Pettinicchi, Juan Criniti, Agustín Pappolla, Jimena Miguez, Edgardo Cristiano, Liliana Patrucco, Susana Liwacki, Verónica Tkachuk, María E Balbuena, Carlos Vrech, Norma Deri, Jorge Correale, Mariano Marrodan, María C Ysrraelit, Felisa Leguizamon, Geraldine Luetic, María L Menichini, Darío Tavolini, Carolina Mainella, Gisela Zanga, Marcos Burgos, Javier Hryb, Andrés Barboza, Luciana Lazaro, Ricardo Alonso, Nora Fernández Liguori, Débora Nadur, Marina Alonso Serena, Alejandro Caride, Friedemann Paul, Juan I Rojas","doi":"10.1177/20552173231205444","DOIUrl":null,"url":null,"abstract":"<p><p>We aimed to evaluate mortality and causes of death among Argentinean neuromyelitis optica spectrum disorder (NMOSD) patients and identify predictors of death. Retrospective study included 158 NMOSD patients and 11 (7%) patients died after 11 years of follow-up for a total exposure time of 53,345 days with an overall incidence density of 2.06 × 10.000 patients/day (95% CI 1.75-2.68). Extensive cervical myelitis with respiratory failure (45%) was the most frequent cause of death. Older age (HR = 2.05, <i>p</i> = 0.002) and higher disability score (HR = 2.30, <i>p</i> < 0.001) at disease onset were independent predictors of death. We found an 11-year mortality rate of 7% in Argentinean NMOSD patients.</p>","PeriodicalId":18961,"journal":{"name":"Multiple Sclerosis Journal - Experimental, Translational and Clinical","volume":"9 4","pages":"20552173231205444"},"PeriodicalIF":2.5000,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/68/4c/10.1177_20552173231205444.PMC10580714.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Multiple Sclerosis Journal - Experimental, Translational and Clinical","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/20552173231205444","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/10/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
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Abstract
We aimed to evaluate mortality and causes of death among Argentinean neuromyelitis optica spectrum disorder (NMOSD) patients and identify predictors of death. Retrospective study included 158 NMOSD patients and 11 (7%) patients died after 11 years of follow-up for a total exposure time of 53,345 days with an overall incidence density of 2.06 × 10.000 patients/day (95% CI 1.75-2.68). Extensive cervical myelitis with respiratory failure (45%) was the most frequent cause of death. Older age (HR = 2.05, p = 0.002) and higher disability score (HR = 2.30, p < 0.001) at disease onset were independent predictors of death. We found an 11-year mortality rate of 7% in Argentinean NMOSD patients.
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