{"title":"Role of Flavonoids in Modulation of Mitochondria Dynamics during Oxidative Stress.","authors":"Sachindra Kumar, Vishal Chhabra, Smita Shenoy, Rajni Daksh, Velayutham Ravichandiran, Ravindra Shantakumar Swamy, Nitesh Kumar","doi":"10.2174/0113895575259219230920093214","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Flavonoids are a widespread category of naturally occurring polyphenols distinguished by the flavan nucleus in plant-based foods and beverages, known for their various health benefits. Studies have suggested that consuming 150-500 mg of flavonoids daily is beneficial for health. Recent studies suggest that flavonoids are involved in maintaining mitochondrial activity and preventing impairment of mitochondrial dynamics by oxidative stress.</p><p><strong>Objective: </strong>This review emphasized the significance of studying the impact of flavonoids on mitochondrial dynamics, oxidative stress, and inflammatory response.</p><p><strong>Methods: </strong>This review analysed and summarised the findings related to the impact of flavonoids on mitochondria from publicly available search engines namely Pubmed, Scopus, and Web of Science.</p><p><strong>Description: </strong>Any disruption in mitochondrial dynamics can contribute to cellular dysfunction and diseases, including cancer, cardiac conditions, and neurodegeneration. Flavonoids have been shown to modulate mitochondrial dynamics by regulating protein expression involved in fission and fusion events. Furthermore, flavonoids exhibit potent antioxidant properties by lowering the production of ROS and boosting the performance of antioxidant enzymes. Persistent inflammation is a characteristic of many different disorders. This is because flavonoids also alter the inflammatory response by controlling the expression of numerous cytokines and chemokines involved in the inflammatory process. Flavonoids exhibit an impressive array of significant health effects, making them an effective therapeutic agent for managing various disorders. Further this review summarised available mechanisms underlying flavonoids' actions on mitochondrial dynamics and oxidative stress to recognize the optimal dose and duration of flavonoid intake for therapeutic purposes.</p><p><strong>Conclusion: </strong>This review may provide a solid foundation for developing targeted therapeutic interventions utilizing flavonoids, ultimately benefiting individuals afflicted with various disorders.</p>","PeriodicalId":18548,"journal":{"name":"Mini reviews in medicinal chemistry","volume":" ","pages":"908-919"},"PeriodicalIF":3.3000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mini reviews in medicinal chemistry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2174/0113895575259219230920093214","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Flavonoids are a widespread category of naturally occurring polyphenols distinguished by the flavan nucleus in plant-based foods and beverages, known for their various health benefits. Studies have suggested that consuming 150-500 mg of flavonoids daily is beneficial for health. Recent studies suggest that flavonoids are involved in maintaining mitochondrial activity and preventing impairment of mitochondrial dynamics by oxidative stress.
Objective: This review emphasized the significance of studying the impact of flavonoids on mitochondrial dynamics, oxidative stress, and inflammatory response.
Methods: This review analysed and summarised the findings related to the impact of flavonoids on mitochondria from publicly available search engines namely Pubmed, Scopus, and Web of Science.
Description: Any disruption in mitochondrial dynamics can contribute to cellular dysfunction and diseases, including cancer, cardiac conditions, and neurodegeneration. Flavonoids have been shown to modulate mitochondrial dynamics by regulating protein expression involved in fission and fusion events. Furthermore, flavonoids exhibit potent antioxidant properties by lowering the production of ROS and boosting the performance of antioxidant enzymes. Persistent inflammation is a characteristic of many different disorders. This is because flavonoids also alter the inflammatory response by controlling the expression of numerous cytokines and chemokines involved in the inflammatory process. Flavonoids exhibit an impressive array of significant health effects, making them an effective therapeutic agent for managing various disorders. Further this review summarised available mechanisms underlying flavonoids' actions on mitochondrial dynamics and oxidative stress to recognize the optimal dose and duration of flavonoid intake for therapeutic purposes.
Conclusion: This review may provide a solid foundation for developing targeted therapeutic interventions utilizing flavonoids, ultimately benefiting individuals afflicted with various disorders.
背景：黄酮类化合物是一类广泛存在的天然多酚，以植物性食品和饮料中的黄烷核为特征，以其多种健康益处而闻名。研究表明，每天摄入150-500毫克黄酮类化合物对健康有益。最近的研究表明，黄酮类化合物参与维持线粒体活性和防止氧化应激对线粒体动力学的损害。目的：本综述强调研究黄酮类化合物对线粒体动力学、氧化应激和炎症反应的影响的意义。方法：本综述分析并总结了公开搜索引擎（即Pubmed、Scopus和Web of Science）中与黄酮类化合物对线粒体影响有关的研究结果。说明：线粒体动力学的任何破坏都可能导致细胞功能障碍和疾病，包括癌症、心脏病和神经退行性变。黄酮类化合物已被证明通过调节参与分裂和融合事件的蛋白质表达来调节线粒体动力学。此外，黄酮类化合物通过降低ROS的产生和提高抗氧化酶的性能而表现出强大的抗氧化特性。持续性炎症是许多不同疾病的特征。这是因为类黄酮还通过控制参与炎症过程的多种细胞因子和趋化因子的表达来改变炎症反应。黄酮类化合物表现出一系列令人印象深刻的显著健康效果，使其成为治疗各种疾病的有效药物。此外，这篇综述总结了类黄酮对线粒体动力学和氧化应激作用的可用机制，以确定用于治疗目的的类黄酮摄入的最佳剂量和持续时间。结论：这篇综述可能为开发利用黄酮类化合物的靶向治疗干预措施提供坚实的基础，最终使患有各种疾病的个体受益。
期刊介绍：
The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines.
Mini-Reviews in Medicinal Chemistry covers all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies.
Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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