Oral melanoacanthoma: Clinicopathological and immunohistochemical features of a case series and a scoping review

IF 2.7 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral Pathology & Medicine Pub Date : 2023-10-18 DOI:10.1111/jop.13495

Thalita Soares Tavares, Adriana Aparecida Silva da Costa, Felipe da Mata Camargos, Ricardo Santiago Gomez, Cassiano Francisco Weege Nonaka, Pollianna Muniz Alves, Elismauro Francisco Mendonça, Sebastião Silvério Sousa-Neto, Ana Carolina Uchoa Vasconcelos, Sandra Beatriz Chaves Tarquínio, Patrícia Carlos Caldeira

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引用次数: 0

Abstract

Background

This study presents a case series and scoping review of oral melanoacanthoma to examine its clinical, histopathological, and immunohistochemical characteristics.

Methods

Nine cases of oral melanoacanthoma were included in the case series. Clinical data were collected from biopsy charts. Hematoxylin–eosin and immunohistochemistry for TRP2, CD3, and CD20 were done. For the scoping review, MEDLINE/PubMed, Web of Science, EMBASE, and Scopus were searched.

Results

Case series: The mean age was 46.8 years (female-to-male ratio 2:1). Lesion's mean size was 11.0 mm (±9.3). Lesions were mainly macular (77.8%) with brown or black coloration (88.9%) and often affected multiple sites (44.4%). The evolution time ranged from 15 days to 96 months. Lesions commonly showed epithelial acanthosis (66.7%), spongiosis (55.6%), exocytosis (77.8%), melanin incontinence (88.9%), and inflammatory infiltrate in the lamina propria (77.8%), from which all showed lymphocytes. TRP2-positive melanocytes were identified in the basal and spinous layer of all cases, and in the superficial layer of three cases. CD3-positive cells predominate over the CD20-positive. Scoping review: 85 cases of oral melanoacanthoma were retrieved from 55 studies. Patients were primarily female (female-to-male ratio 2.2:1), black-skinned (64.1%), with a mean age of 36.13 (± 17.24). Lesions were flat (81.9%), often brown (62.4%). Buccal mucosa was the preferred site (32.9%), followed by multiple sites (28.2%).

Conclusion

Oral melanoacanthoma mainly affects women across a wide age range, with lesions commonly appearing as brown/black macules, particularly on the buccal mucosa. TRP2-positive melanocytes and T-lymphocytes were consistently found and could participate in oral melanoacanthoma pathogenesis.

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口腔黑棘皮瘤：一系列病例的临床病理和免疫组织化学特征及范围界定综述。

背景：本研究介绍了口腔黑棘皮瘤的病例系列和范围综述，以检查其临床、组织病理学和免疫组织化学特征。方法：将9例口腔黑棘皮瘤纳入病例系列。临床数据是从活检图表中收集的。对TRP2、CD3和CD20进行苏木精-伊红和免疫组织化学检测。对于范围界定审查，检索了MEDLINE/PubMed、Web of Science、EMBASE和Scopus。结果：病例系列：平均年龄46.8岁年（男女比例2:1）。病变的平均大小为11.0 mm（±9.3）。病变主要为黄斑（77.8%），呈棕色或黑色（88.9%），常累及多个部位（44.4%）天到96 月。病变常见上皮棘皮病（66.7%）、海绵状血管病（55.6%）、胞吐症（77.8%）、黑色素失禁（88.9%）和固有层炎症浸润（77.8%，均可见淋巴细胞。TRP2阳性的黑色素细胞在所有病例的基底层和棘层中都有发现，在三例病例的浅表层中也有发现。CD3阳性细胞比CD20阳性细胞占优势。范围综述：从55项研究中检索到85例口腔黑棘皮瘤。患者主要为女性（男女比例2.2:1），黑皮肤（64.1%），平均年龄36.13（± 17.24）。病变为扁平（81.9%），常为棕色（62.4%）。颊粘膜是首选部位（32.9%），其次是多个部位（28.2%）。TRP2阳性的黑色素细胞和T淋巴细胞一直存在，并可能参与口腔黑棘皮瘤的发病机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Oral Pathology & Medicine 医学-病理学

CiteScore

5.90

自引率

6.10%

发文量

121

审稿时长

4-8 weeks

期刊介绍： The aim of the Journal of Oral Pathology & Medicine is to publish manuscripts of high scientific quality representing original clinical, diagnostic or experimental work in oral pathology and oral medicine. Papers advancing the science or practice of these disciplines will be welcomed, especially those which bring new knowledge and observations from the application of techniques within the spheres of light and electron microscopy, tissue and organ culture, immunology, histochemistry and immunocytochemistry, microbiology, genetics and biochemistry.