Demographic and Clinical Characteristics of Familial and Sporadic Multiple Sclerosis Patients.

IF 1.7 Q2 MEDICINE, GENERAL & INTERNAL

International Journal of Preventive Medicine Pub Date : 2023-06-22 eCollection Date: 2023-01-01 DOI:10.4103/ijpvm.ijpvm_187_22

Shahrzad Mokhtari, Shakiba Houshi, Omid Mirmosayyeb, Mahdi Barzegar, Alireza Afshari-Safavi, Majid Ghasemi, Vahid Shaygannejad

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引用次数: 0

Abstract

Background: Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating, immune-mediated disease of the central nervous system. It is still unestablished whether heredity correlates with the disease's progression and severity.

Methods: This study includes the patients with MS seen in the MS clinic of Kashani Hospital, affiliated with Isfahan University of Medical Sciences, from January 2019 to January 2020. We gathered data regarding the demographic and clinical characteristics, such as type of disease and family history of MS. Patients were grouped based on having relatives with MS. We compared demographic and clinical characteristics between those with a family history of MS (familial MS: FMS) and those without a family history of MS (sporadic MS: SMS).

Results: We included 2,929 MS patients, 523 (17.2%) with FMS and 2,406 (82.8%) with SMS. Patients with FMS were found to have active lesions in the thoracic spine more frequently than those with SMS (P = 0.022). We also found differences in the distribution of gender (P = 0.036) and the frequency of having active brain lesions (P = .024) among patients with FMS and SMS. No difference was found between the demographic/clinical characteristics and the number of affected relatives in the family.

Conclusions: Significant differences were found among different groups of patients in terms of demographical and clinical characteristics.

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家族性和散发性多发性硬化症患者的人口学和临床特征。

背景：多发性硬化症是一种慢性、炎症性、脱髓鞘、免疫介导的中枢神经系统疾病。遗传是否与疾病的进展和严重程度相关尚不清楚。方法：本研究包括2019年1月至2020年1月在伊斯法罕医学科学大学附属Kashani医院MS诊所就诊的MS患者。我们收集了有关人口统计学和临床特征的数据，如多发性硬化症的疾病类型和家族史。根据有多发性痴呆症亲属的情况对患者进行分组。我们比较了有多发症家族史（家族性多发性脑脊髓炎：FMS）和无多发性脊髓炎家族史（散发性多发症：SMS）的患者的人口统计和临床特征，523例（17.2%）患有FMS，2406例（82.8%）患有SMS。FMS患者的胸椎活动性病变发生率高于SMS患者（P=0.022）。我们还发现，FMS和SMS患者的性别分布（P=0.036）和活动性脑病变发生率（P=0.024）存在差异。在人口统计学/临床特征和家庭中受影响亲属的数量之间没有发现差异。结论：不同人群在人口学和临床特征方面存在显著差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Preventive Medicine MEDICINE, GENERAL & INTERNAL-

CiteScore

3.20

自引率

4.80%

发文量

107

期刊介绍： International Journal of Preventive Medicine, a publication of Isfahan University of Medical Sciences, is a peer-reviewed online journal with Continuous print on demand compilation of issues published. The journal’s full text is available online at http://www.ijpvmjournal.net. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository. The journal will cover technical and clinical studies related to health, ethical and social issues in field of Preventive Medicine. Articles with clinical interest and implications will be given preference.