Systematic exploration of a decade of publications on psychiatric genetics in Latin America

IF 1.6 3区 医学 Q3 GENETICS & HEREDITY
Diana Garro-Núñez, María Jesús Picado-Martínez, Erika Espinoza-Campos, Daniela Ugalde-Araya, Gabriel Macaya, Henriette Raventós, Gabriela Chavarría-Soley
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引用次数: 0

Abstract

Psychiatric disorders have a great impact in terms of mortality, morbidity, and disability across the lifespan. Considerable effort has been devoted to understanding their complex and heterogeneous genetic architecture, including diverse ancestry populations. Our aim was to review the psychiatric genetics research published with Latin American populations from 2010 to 2019, and classify it according to country of origin, type of analysis, source of funding, and other variables. We found that most publications came from Brazil, Mexico, and Colombia. Also, local funds are generally not large enough for genome-wide studies in Latin America, with the exception of Brazil and Mexico; larger studies are often done in collaboration with international partners, mostly funded by US agencies. In most of the larger studies, the participants are individuals of Latin American ancestry living in the United States, which limits the potential for exploring the complex gene–environment interaction. Family studies, traditionally strong in Latin America, represent about 30% of the total research publications. Scarce local resources for research in Latin America have probably been an important limitation for conducting bigger and more complex studies, contributing to the reduced representation of these populations in global psychiatric genetics studies. Increasing diversity must be a goal to improve generalizability and applicability in clinical settings.

对拉丁美洲精神遗传学十年出版物的系统探索。
精神疾病对整个生命周期的死亡率、发病率和残疾有很大影响。人们花了大量的精力来理解它们复杂和异质的遗传结构,包括不同的祖先群体。我们的目的是回顾2010年至2019年在拉丁美洲人群中发表的精神遗传学研究,并根据来源国、分析类型、资金来源和其他变量对其进行分类。我们发现,大多数出版物来自巴西、墨西哥和哥伦比亚。此外,除巴西和墨西哥外,当地资金通常不足以用于拉丁美洲的全基因组研究;大型研究通常是与国际合作伙伴合作进行的,这些合作伙伴大多由美国机构资助。在大多数大型研究中,参与者都是居住在美国的拉丁美洲血统的个体,这限制了探索复杂基因与环境相互作用的潜力。传统上在拉丁美洲占主导地位的家庭研究约占研究出版物总数的30%。拉丁美洲当地研究资源匮乏可能是进行更大规模、更复杂研究的一个重要限制,导致这些人群在全球精神遗传学研究中的代表性降低。增加多样性必须是提高临床环境中的可推广性和适用性的目标。
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来源期刊
CiteScore
5.90
自引率
7.10%
发文量
40
审稿时长
4-8 weeks
期刊介绍: Neuropsychiatric Genetics, Part B of the American Journal of Medical Genetics (AJMG) , provides a forum for experimental and clinical investigations of the genetic mechanisms underlying neurologic and psychiatric disorders. It is a resource for novel genetics studies of the heritable nature of psychiatric and other nervous system disorders, characterized at the molecular, cellular or behavior levels. Neuropsychiatric Genetics publishes eight times per year.
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