Polydopamine functionalized polyurethane shape memory sponge with controllable expansion performance triggered by near-infrared light for incompressible hemorrhage control

IF 5.4 2区医学 Q1 BIOPHYSICS

Colloids and Surfaces B: Biointerfaces Pub Date : 2023-10-13 DOI:10.1016/j.colsurfb.2023.113590

Feng Sang , Luqi Pan , Zhixiao Ji , Bingxu Zhang , Zhizhen Meng , Lina Cao , Jing Zhang , Xujian Li , Xiao Yang , Changcan Shi

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引用次数: 0

Abstract

Uncontrolled expansion of shape memory sponges face a significant challenge in the treatment of lethal incompressible hemorrhage, which can lead to blood overflow or damage to the surrounding tissue. Herein, we developed a polydopamine functionalized polyurethane shape memory sponge (PDA-TPI-PU) with a controllable degree of expansion by near-infrared (NIR) light-triggered stimulation for the treatment of incompressible hemorrhage. The sponge has excellent liquid absorption performance and robust mechanical strength as well as good photothermal conversion ability. Under NIR light of 0.32 W/cm², the maximum recovery rate of the fixed-shape compression sponge was 91% within 25 s in air and 80% within 25 s in blood. In the SD rat liver penetrating injury model, compared with commercial medical gelatin sponge and PVA sponge, the PDA-TPI-PU sponge could effectively control the bleeding under the NIR light irradiation and did not cause excessive compression of the wound. The sponge with these characteristics shows potential application prospects as a hemostatic material.

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聚多巴胺功能化聚氨酯形状记忆海绵，具有由近红外光触发的可控膨胀性能，用于不可压缩的出血控制。

形状记忆海绵的不受控制的扩张在治疗致命的不可压缩出血方面面临着重大挑战，这种出血可能导致血液溢出或损伤周围组织。在此，我们开发了一种聚多巴胺功能化聚氨酯形状记忆海绵（PDA-TPI-PU），通过近红外（NIR）光触发刺激，其膨胀程度可控，用于治疗不可压缩性出血。该海绵具有优异的液体吸收性能和坚固的机械强度以及良好的光热转换能力。在0.32W/cm2的NIR光照下，固定形状压缩海绵在空气中25秒内的最大回收率为91%，在血液中25秒内为80%。在SD大鼠肝脏穿透性损伤模型中，与市售医用明胶海绵和PVA海绵相比，PDA-TPI-PU海绵在近红外光照射下能有效控制出血，不会对伤口造成过度压迫。具有这些特性的海绵作为止血材料显示出潜在的应用前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Colloids and Surfaces B: Biointerfaces 生物-材料科学：生物材料

CiteScore

11.10

自引率

3.40%

发文量

730

审稿时长

42 days

期刊介绍： Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields. Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication. The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.